Knockout Resources to Conquer Human Disease
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Breaking news: More Live Knockout Lines Available, Including Conditionals
195 new lines of knockout mice are now available in a shorter period of time than knockout mice that are developed from the embryonic stem cell clones. TIGM can provide researchers with 129SvEv x C57BL/6 heterozygous knockout mice within 16 to 20 weeks after a signed MTA has been received by TIGM. These lines are included in TIGM's database which can be searched at www.tigm.org/database. We also now have more than 100 lines available as conditional mutants in the 129SvEv background. Download the list of genes with available conditional mutants: TIGM Conditional Genes Breaking news: Publication in Genome Research describes the TIGM C57 library Large-scale gene trapping in C57BL/6N mouse embryonic stem cells Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A. Download Full Text | |
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TIGM maintains the world's largest C57BL/6N gene trap library, a knockout mouse embryonic stem (ES) cell resource that contains over 350,000 cell lines representing more than 10,000 unique genes. This library contains multiple clones for each gene to ensure the successful creation of knockout mice.
TIGM also has access to a privately held 129/SvEvBrd gene trap library. This gene trap library contains more than 270,000 sequence-tagged embryonic stem cell clones in the 129/SvEvBrd mouse strain representing mutations in over 9,000 genes. The National Institutes of Health has obtained rights to a subset of these lines, allowing TIGM to make them available for distribution to the academic research community on a subsidized basis. Together, these established resources provide unparalleled coverage of the mouse genome with over 640,000 cell lines representing over 13,000 genes. TIGM provides ES cell clones and knockout mice to the international scientific community. |
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The Texas A&M Institute for Genomic Medicine (TIGM) is a part of the Texas A&M University System as a joint research institute of the Texas A&M University and the Texas A&M Health Science Center. TIGM utilizes advanced technologies to discover breakthroughs in science and medicine and accelerate the pace of medical discoveries. TIGM accomplishes this through internal research and collaborations with other institutions. TIGM also maintains the world's largest library of mouse knockout embryonic stem cells and provides both ES cells and mice to academic and commercial institutions around the world.
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2008 Presentations
2008 Conference Schedule
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