Publications Using TIGM Mice
  1. Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice. Sarah L. Kempster, Gusztav Belteki, Diana Licence, D. Stephen Charnock-Jones, and Gordon C. S. Smith. Am J Physiol Endocrinol Metab. 2012 Jan;302(1)

  2. Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation. Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF. Science. 2011 Nov 11;334(6057):809-13.

  3. Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM Jr. Hypertension. 2011 Oct;58(4):672-8.

  4. Fuz regulates craniofacial development through tissue specific responses to signaling factors. Zhang Z, Wlodarczyk BJ, Niederreither K, Venugopalan S, Florez S, Finnell RH, Amendt BA. PLoS One. 2011;6(9)

  5. Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C. Immunity 2011 Oct 28;35(4):611-21

  6. Behavioural phenotyping of knockout mice for the sigma-1 (σ(1)) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations. Chevallier N, Keller E, Maurice T. J Psychopharmacol. 2011 Jul;25(7):960-75.

  7. Functional and Topological Analysis of Pen-2, the Fourth Subunit of the Gamma-secretase Complex. Leen Bammens, Lucía Chávez-Gutiérrez, Alexandra Tolia, An Zwijsen, and Bart De Strooper. J. Biol. Chem. 2011; 286:12271-12282.

  8. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H. Development. 2011 May;138(10):1925-34.

  9. Traumatic brain injury in mice lacking the K channel, TREK-1. Namiranian K, Brink CD, Goodman JC, Robertson CS, Bryan RM Jr. J Cereb Blood Flow Metab. 2011 Mar;31(3):e1-6.

  10. Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase. Martina Griesberger, Alexander Kollau, Gerald Wölkart, M. Verena Wenzl, Matteo Beretta, Michael Russwurm, Doris Koesling, Kurt Schmidt, Antonius C. F. Gorren, and Bernd Mayer. Mol. Pharmacol. 2011 Mar; 79(3):541-8.

  11. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Liu J, Gao BB, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP. Nat Med. 2011 Feb;17(2):206-10.

  12. RGS6/Gbeta5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Posokhova E, Wydeven N, Allen KL, Wickman K, Martemyanov KA. Circ Res. 2010 Nov 26;107(11):1350-4.

  13. RGS6, a modulator of parasympathetic activation in heart. Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, Li J, Stewart A, Swaminathan PD, Ibeawuchi SR, Shepherd A, Chen CK, Kutschke W, Mohler PJ, Mohapatra DP, Anderson ME, Fisher RA. Circ Res. 2010 Nov 26;107(11):1345-9

  14. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. Inflamm Bowel Dis. 2011 Aug;17(8):1651-64.

  15. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF. Nat Neurosci. 2010 Sep;13(9):1113-9.

  16. Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Wu CS, Zhu J, Wager-Miller J, Wang S, O'Leary D, Monory K, Lutz B, Mackie K, Lu HC. Eur J Neurosci. 2010 Sep;32(5):693-706

  17. Transient Receptor Potential Melastatin 6 Knockout Mice Are Lethal whereas Heterozygous Deletion Results in Mild Hypomagnesemia. Woudenberg-Vrenken TE, Sukinta A, van der Kemp AW, Bindels RJ, Hoenderop JG. Nephron Physiol. 2010 Sep 1;117(2):p11-p19.

  18. IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50. Conner JR, Smirnova II, Moseman AP, Poltorak A. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11477-82.

  19. Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. Iskandar BJ, Rizk E, Meier B, Hariharan N, Bottiglieri T, Finnell RH, Jarrard DF, Banerjee RV, Skene JH, Nelson A, Patel N, Gherasim C, Simon K, Cook TD, Hogan KJ. J Clin Invest. 2010 May 3;120(5):1603-16.
    20. Also see commentary:
    Neuronal injury: folate to the rescue? Kronenberg G, Endres M.I. J Clin Invest. 2010 May 3;120(5):1383-6.
  20. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S. Cell Metab. 2010 Apr 7;11(4):311-9.

  21. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ, Bryan RM Jr. Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R461-9.

  22. The SLO3 sperm-specific potassium channel plays a vital role in male fertility. Santi CM, Martínez-López P, de la Vega-Beltrán JL, Butler A, Alisio A, Darszon A, Salkoff L. FEBS Lett. 2010 Mar 5;584(5):1041-6.

  23. RGS7 and -11 Complexes Accelerate the ON-Bipolar Cell Light Response. Jianmei Zhang, Brett G. Jeffrey, Catherine W. Morgans, Neal S. Burke, Tammie L. Haley, Robert M. Duvoisin, and R. Lane Brown. Invest. Ophthalmol. Vis. Sci. 2010 Feb;51(2):1121-9.

  24. Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. Lin A, Hokugo A, Choi J, Nishimura I. Am J Pathol. 2010 Jan;176(1):108-21.

  25. DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke W. Tu, X. Xu, L. Peng, X. Zhong, W. Zhang, M. Soundarapandian, C. Balel, M. Wang, N. Jia, W. Zhang, et al. Cell. 2010 Jan 22; 140(2): 222-234.

  26. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Cimen H, Han MJ, Yang Y, Tong Q, Koc H, Koc EC. Biochemistry. 2010 Jan 19;49(2):304-11.

  27. NAD<+>-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. J Biol Chem. 2010 Mar 5;285(10):7417-29.

  28. TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Morgans CW, Zhang J, Jeffrey BG, Nelson SM, Burke NS, Duvoisin RM, Brown RL. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19174-8.

  29. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Chang M, Jin W, Sun SC. Nat Immunol. 2009 Oct;10(10):1089-95.

  30. MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN. J Biol Chem. 2009 Feb 27;284(9):5986-93.

Publication by TIGM Scientists

  1. A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Salojin KV, Cabrera RM, Sun W, Chang WC, Lin C, Duncan L, Platt KA, Read R, Vogel P, Liu Q, Finnell RH, Oravecz T. Blood. 2011 May 5;117(18):4895-904.

  2. Fuz Controls the Morphogenesis and Differentiation of Hair Follicles through the Formation of Primary Cilia. Daisy Dai, Huiping Zhu, Bogdan Wlodarczyk, Lei Zhang, Li Li, Allen G. Li4, Richard H. Finnell, Dennis R. Roop and Jiang Chen. Journal of Investigative Dermatology 2011 Feb;131(2):302-10.

  3. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Gray RS, Abitua PB, Wlodarczyk BJ, Szabo-Rogers HL, Blanchard O, Lee I, Weiss GS, Liu KJ, Marcotte EM, Wallingford JB, Finnell RH. Nat Cell Biol. 2009 Oct;11(10):1225-32.

  4. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.Jakubowski H, Perla-Kaján J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. FASEB J. 2009 Jun;23(6):1721-7.

  5. Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Wong RL, Wlodarczyk BJ, Min KS., Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP and Finnell RH. Hum. Mol. Genet. 2008 Feb 15; 17(4):587-601.

Publication describing our library and technology

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A. Genome Res. 2008 Oct;18(10):1670-9.