F-box and Leucine-rich Repeat Protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. Ruiz JC, Walker SD, Anderson SA, Eisenstein RS, Bruick RK. J Biol Chem. 2012 Nov 7.

Age-Dependent MicroRNA Control of Synaptic Plasticity in 22q11 Deletion Syndrome and Schizophrenia. Earls LR, Fricke RG, Yu J, Berry RB, Baldwin LT, Zakharenko SS. J Neurosci. 2012 Oct 10;32(41):14132-44.

Alanine-Glyoxylate Aminotransferase-2 Metabolizes Endogenous Methylarginines, Regulates NO, and Controls Blood Pressure. Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahey M, Salama A; The International Consortium for Blood Pressure Genome-Wide Association Studies, Wheeler DC, Leiper J. Arterioscler Thromb Vasc Biol. 2012 Sep 27.

The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants. Zelano J, Mikulovic S, Patra K, Kühnemund M, Larhammar M, Emilsson L, Leao R, Kullander K. Exp Neurol. 2012 Sep 26.

Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes. Nordstrand LM, Furu K, Paulsen J, Rognes T, Klungland A. Nucleic Acids Res. 2012 Sep 10.

Protective role of antithrombin in mouse models of liver injury. Guerrero JA, Teruel R, Martínez C, Arcas I, Martínez-Martínez I, de la Morena-Barrio ME, Vicente V, Corral J.J Hepatol. 2012 June 26.[Request Info on antithrombin knockout]

GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD. Science. 2012 Apr 27;336(6080):481-5. [Request Info on Gbp5 knockout]

Characterization of an arachidonic acid-deficient (Fads1 knock-out) mouse model. Fan YY, Monk JM, Hou TY, Callaway E, Vincent L, Weeks B, Yang P, Chapkin RS. J Lipid Res. 2012 Apr 25.

Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney. Lier N, Gresko N, Di Chiara M, Loffing-Cueni D, Loffing J. Histochem Cell Biol. 2012 Mar 31.

Phospholipid Scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Talukder AH, Bao M, Kim TW, Facchinetti V, Hanabuchi S, Bover L, Zal T, Liu YJ. Cell Res. 2012 Mar 27.

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB. Yang C, Jin C, Li X, Wang F, McKeehan WL, Luo Y. PLoS One. 2012 Mar 19.

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain. Pichery M, Mirey E, Mercier P, Lefrancais E, Dujardin A, Ortega N, Girard JP. J Immunol. 2012 Feb 27.

Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice. Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. J Physiol. 2012 Jan 23.

FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription. De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA, Di Ilio C, Melino G, Sette C, De Laurenzi V. Oncogene. 2012 Feb 2;31(5):573-82.

Analysis of Gga Null Mice Demonstrates a Non-Redundant Role for Mammalian GGA2 during Development. Govero J, Doray B, Bai H, Kornfeld S. PLoS One. 2012 Jan 26;7(1)

Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin. Lizak M, Yarovinsky TO. Cell Host Microbe. Cell Host Microbe.2012 Jan 19;11(1):70-80.

Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice. Kempster SL, Belteki G, Licence D, Charnock-Jones DS, Smith GC.Am J Physiol Endocrinol Metab. 2012 Jan;302(1)

Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis. Welsh KJ, Lewis CT, Boyd S, Braun MC, Actor JK. Clin Dev Immunol. 2012;2012:429675

Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants. Villard V, Meunier J, Chevallier N, Maurice T. J Pharmacol Sci. 2011;115(3):279-92.

Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice. Li Q, Peng X, Yang H, Wang H, Shu Y. Mol Pharm. 2011 Dec 5;8(6):2476-83.

The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons. Bachy I, Franck MC, Li L, Abdo H, Pattyn A, Ernfors P. Dev Biol. 2011 Dec 1;360(1):77-86.

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation. Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF. Science. 2011 Nov 11;334(6057):809-13. [Request Info on Mgll knockout]

Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM Jr. Hypertension. 2011 Oct;58(4):672-8.

Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C. Immunity 2011 Oct 28;35(4):611-21

Behavioural phenotyping of knockout mice for the sigma-1 (σ(1)) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations. Chevallier N, Keller E, Maurice T. J Psychopharmacol. 2011 Jul;25(7):960-75.

The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC. Nat Immunol. 2011 Aug 28;12(10):1002-9. [Request Info on Peli1 knockout]

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG. Islets. 2011 May-Jun;3(3):121-8.

A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD. Science. 2011 May 6;332(6030):717-21. [Request Info on Gbp1 knockout]

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H. Development. 2011 May;138(10):1925-34.

Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B. J. Biol. Chem. 2011 Apr 8;286(14):12271-82.

Traumatic brain injury in mice lacking the K channel, TREK-1. Namiranian K, Brink CD, Goodman JC, Robertson CS, Bryan RM Jr. J Cereb Blood Flow Metab. 2011 Mar;31(3):e1-6.

Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase. Martina Griesberger, Alexander Kollau, Gerald Wölkart, M. Verena Wenzl, Matteo Beretta, Michael Russwurm, Doris Koesling, Kurt Schmidt, Antonius C. F. Gorren, and Bernd Mayer. Mol. Pharmacol. 2011 Mar; 79(3):541-8.

Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Liu J, Gao BB, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP. Nat Med. 2011 Feb;17(2):206-10.

RGS6/Gbeta5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Posokhova E, Wydeven N, Allen KL, Wickman K, Martemyanov KA. Circ Res. 2010 Nov 26;107(11):1350-4.

RGS6, a modulator of parasympathetic activation in heart. Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, Li J, Stewart A, Swaminathan PD, Ibeawuchi SR, Shepherd A, Chen CK, Kutschke W, Mohler PJ, Mohapatra DP, Anderson ME, Fisher RA. Circ Res. 2010 Nov 26;107(11):1345-9

Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice. Hermanstyne TO, Kihira Y, Misono K, Deitchler A, Yanagawa Y, Misonou H. J Comp Neurol. 2010 Nov 1;518(21):4298-310.

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. Inflamm Bowel Dis. 2011 Aug;17(8):1651-64.

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF. Nat Neurosci. 2010 Sep;13(9):1113-9.[Request Info on Mgll knockout]

Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Wu CS, Zhu J, Wager-Miller J, Wang S, O’Leary D, Monory K, Lutz B, Mackie K, Lu HC. Eur J Neurosci. 2010 Sep;32(5):693-706

Transient Receptor Potential Melastatin 6 Knockout Mice Are Lethal whereas Heterozygous Deletion Results in Mild Hypomagnesemia. Woudenberg-Vrenken TE, Sukinta A, van der Kemp AW, Bindels RJ, Hoenderop JG. Nephron Physiol. 2010 Sep 1;117(2):p11-p19.

IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50. Conner JR, Smirnova II, Moseman AP, Poltorak A. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11477-82.

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S. Cell Metab. 2010 Apr 7;11(4):311-9.

Characterization of murine SIRT3 transcript variants and corresponding protein products. Yang Y, Hubbard BP, Sinclair DA, Tong Q. J Cell Biochem. 2010 Nov 1;111(4):1051-8.

Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ, Bryan RM Jr. Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R461-9.

The SLO3 sperm-specific potassium channel plays a vital role in male fertility. Santi CM, Martínez-López P, de la Vega-Beltrán JL, Butler A, Alisio A, Darszon A, Salkoff L. FEBS Lett. 2010 Mar 5;584(5):1041-6.

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, Lee E, Gao J, Bredemeyer AL, Helmink BA, Zavadil J, Sleckman BP, Palomero T, Ferrando A, Aifantis I. Nat Immunol. 2010 Mar;11(3):207-15.

RGS7 and -11 Complexes Accelerate the ON-Bipolar Cell Light Response. Jianmei Zhang, Brett G. Jeffrey, Catherine W. Morgans, Neal S. Burke, Tammie L. Haley, Robert M. Duvoisin, and R. Lane Brown. Invest. Ophthalmol. Vis. Sci. 2010 Feb;51(2):1121-9.

Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. Lin A, Hokugo A, Choi J, Nishimura I. Am J Pathol. 2010 Jan;176(1):108-21.

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke W. Tu, X. Xu, L. Peng, X. Zhong, W. Zhang, M. Soundarapandian, C. Balel, M. Wang, N. Jia, W. Zhang, et al. Cell. 2010 Jan 22; 140(2): 222-234.

Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Cimen H, Han MJ, Yang Y, Tong Q, Koc H, Koc EC. Biochemistry. 2010 Jan 19;49(2):304-11.

NAD<+>-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. J Biol Chem. 2010 Mar 5;285(10):7417-29.

TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Morgans CW, Zhang J, Jeffrey BG, Nelson SM, Burke NS, Duvoisin RM, Brown RL. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19174-8.

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Chang M, Jin W, Sun SC. Nat Immunol. 2009 Oct;10(10):1089-95.

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL 3rd, Goodyear LJ, Tong Q. Aging (Albany NY). 2009 Aug 15;1(9):771-83.

MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN. J Biol Chem. 2009 Feb 27;284(9):5986-93.

USE OF COMPOUNDS ACTIVATING SIRT-3 FOR MIMICKING EXERCISE. David A. Sinclair et al. United States Patent Application Publication. Application number: 12/739,428, Publication number: US 2011/0082189 A1 Filing date: Oct 23, 2008

CLONED TRANSMEMBRANE RECEPTOR FOR 24-HYDROXYLATED VITAMIN D COMPOUNDS AND USES THEREOF. Rene St-Arnaud. US Patent Application 2012/0180142 Filing date: Nov 29, 2011

COMPOSITIONS RELATING TO A PHOSPHOPROTEIN AND METHODS OF USE. US Patent Application 20120204273 Filing date: December 22, 2011. Published on August 9, 2012.

Propitious Modulation Fibroblast Quiescence Mediated by Cytokine Expression Mediated from Embryonic Stem Cells.. Shane R, Golovko A, Morpurgo B, Dillberger A, Bonn T, Buz-Zard A. E-Journal of Age Management Medicine. October 2012,.Vol. 7, No 10.

The mammalian gene function resource: the international knockout mouse consortium. . Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Kent Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Francis Stewart A, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. Mamm Genome.2012 Oct;23(9-10):580-6.

Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction. Wallis D, Hill DS, Mendez IA, Abbott LC, Finnell RH, Wellman PJ, Setlow B. Brain Research. 2012 May 7.

Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway.. Boyles AL, Ballard JL, Gorman EB, McConnaughey DR, Cabrera RM, Wilcox AJ, Lie RT, Finnell RH. Hum Reprod.2011 Aug;26(8):2232-8.

A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Salojin KV, Cabrera RM, Sun W, Chang WC, Lin C, Duncan L, Platt KA, Read R, Vogel P, Liu Q, Finnell RH, Oravecz T. Blood. 2011 May 5;117(18):4895-904.

Fuz Controls the Morphogenesis and Differentiation of Hair Follicles through the Formation of Primary Cilia. Daisy Dai, Huiping Zhu, Bogdan Wlodarczyk, Lei Zhang, Li Li, Allen G. Li4, Richard H. Finnell, Dennis R. Roop and Jiang Chen. Journal of Investigative Dermatology 2011 Feb;131(2):302-10.

Fuz regulates craniofacial development through tissue specific responses to signaling factors. Zhang Z, Wlodarczyk BJ, Niederreither K, Venugopalan S, Florez S, Finnell RH, Amendt BA. PLoS One. 2011;6(9)

Teratogenic effects of antiepileptic drugs. Hill DS, Wlodarczyk BJ, Palacios AM, Finnell RH. Expert Rev Neurother. 2010 Jun;10(6):943-59.

Arsenite causes down-regulation of Akt and c-Fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells. Habib GM. J Cell Biochem. 2010 May 15;110(2):363-71.

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. Iskandar BJ, Rizk E, Meier B, Hariharan N, Bottiglieri T, Finnell RH, Jarrard DF, Banerjee RV, Skene JH, Nelson A, Patel N, Gherasim C, Simon K, Cook TD, Hogan KJ. J Clin Invest. 2010 May 3;120(5):1603-16.

Also see commentary:
Neuronal injury: folate to the rescue? Kronenberg G, Endres M.I. J Clin Invest. 2010 May 3;120(5):1383-6.

High-affinity folate receptor in cardiac neural crest migration: a gene knockdown model using siRNA. Rosenquist TH, Chaudoin T, Finnell RH, Bennett GD. Dev Dyn. 2010 Apr;239(4):1136-44.

Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark. Bille C, Pedersen DA, Andersen AM, Mansilla MA, Murray JC, Christensen K, Ballard JL, Gorman EB, Cabrera RM, Finnell RH. Pediatr Res. 2010 Mar;67(3):274-9.

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Gray RS, Abitua PB, Wlodarczyk BJ, Szabo-Rogers HL, Blanchard O, Lee I, Weiss GS, Liu KJ, Marcotte EM, Wallingford JB, Finnell RH. Nat Cell Biol. 2009 Oct;11(10):1225-32.

Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.Jakubowski H, Perla-Kaján J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. FASEB J. 2009 Jun;23(6):1721-7.

Polymorphisms in the neural nicotinic acetylcholine receptor α4 subunit (CHRNA4) are associated with ADHD in a genetic isolate. Wallis D, Arcos-Burgos M, Jain M, Castellanos FX, Palacio JD, Pineda D, Lopera F, Stanescu H, Pineda D, Berg K, Palacio LG, Bailey-Wilson JE, Muenke M. Atten Defic Hyperact Disord. 2009 May;1(1):19-24

Folate Transport and Folate Responsive Developmental Disorders. Gorman EB, Wallis D, Ballard JL, Goin-Kochel RP, Finnell RH. Pteridines. 2009, Vol. 20, Special issue, pp. 156-162.

Review: Genetics of attention deficit/hyperactivity disorder. Wallis D, Russell HF, Muenke M. J Pediatr Psychol. 2008 Nov-Dec;33(10):1085-99

Autoantibodies to folate receptor during pregnancy and neural tube defect risk. Cabrera RM, Shaw GM, Ballard JL, Carmichael SL, Yang W, Lammer EJ, Finnell RH. J Reprod Immunol. 2008 Oct;79(1):85-92.

Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Wong RL, Wlodarczyk BJ, Min KS., Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP and Finnell RH. Hum. Mol. Genet. 2008 Feb 15; 17(4):587-601.