Publications Using TIGM Resources

  1. Deciphering Variation in Fetal Alcohol Spectrum Disorders the Missing Piece: Dad. Thomas, Kara Nichole. Order No. 30872981 Texas A&M University, 2023. United States — Texas: ProQuest. Web. 17 July 2024.
  2. Mouse and human studies support DSTYK loss of function as a low penetrance and variable expressivity risk factor for congenital urinary tract anomalies. Martino J, Liu Q, Vukojevic K, Ke J, Lim TY, Khan A, Gupta Y, Perez A, Yan Z, Milo-Rasouly H, Vena N, Lippa N, Giordano JL, Saraga M, Saraga-Babic M, Westland R, Bodria M, Piaggio G, Bendapudi PK, Iglesias AD, Wapner RJ, Tasic V, Wang F, Ionita-Laza I, Ghiggeri GM, Kiryluk K, Sampogna RV, Mendelsohn CL, D’Agati VD, Gharavi AG, Sanna-Cherchi S. Genet Med. 2023 Sep 21:100983. doi: 10.1016/j.gim.2023.100983. Epub ahead of print. PMID: 37746849
  3. Disruption of Mitochondrial Unfolded Protein Response Results in Telomere Shortening in Mouse Oocytes and Somatic Cells. Cozzolino, M.; Ergun, Y.; Ristori, E.; Garg, A.; Imamoglu, G.; Seli, E. . 2023, 2023051776
  4. Unraveling the role of Slc10a4 in auditory processing and sensory motor gating: implications for neuropsychiatric disorders? Barbara CiralliThawann MalfattiMarkus M. HilscherRichardson N. LeaoChristopher R. CederrothKatarina E. LeaoKlas Kullander.
  5. Six-Transmembrane Epithelial Antigen of Prostate 3 Promotes Hepatic Insulin Resistance and Steatosis. Ting Ding, Siping Chen, Wenchang Xiao, Zhen Liu, Jun Tu, Yongjie Yu, Bizhen Dong, Wenping Chen, Yong Zeng. Journal of Lipid Research, Volume 64, Issue 1, 2023, 100318, ISSN 0022-2275
  6. Metabolic regulation of the proteasome under hypoxia by Poldip2 controls fibrotic signaling in vascular smooth muscle cells. Felipe Paredes, Holly C. Williams, Izabela Suster, Macarena Tejos, Roberto Fuentealba, Bethany Bogan, Claire M. Holden, Alejandra San Martin. Free Radical Biology and Medicine.Volume 195, 2023, Pages 283-297,ISSN 0891-5849
  7. Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis. Zhu, D., Zhang, J., Hashem, J. et al.  J Neuroinflammation 20, 17 (2023)
  8. Preconception paternal alcohol exposure decreases IVF embryo survival and pregnancy success rates in a mouse model. Alexis N Roach, Katherine N Zimmel, Kara N Thomas, Alison Basel, Sanat S Bhadsavle, Michael C Golding.  Molecular Human Reproduction. Volume 29, Issue 2, February 2023, gaad002
  9. SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation. Sanchez, L., Epps, J., Wall, S. et al. Cell Death Differ (2023)
  10. Maternal exposure to ultrafine particles enhances influenza infection during pregnancy. Drury, N.L., Mustapha, T., Shore, R.A. et al.  Part Fibre Toxicol 20, 11 (2023)
  11. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Jean-Louis A. ParmasadKonrad M. RickeMorgan G. StykelBrodie Buchner-DubyEric LianBenjamin NguyenNathalie A. LengacherHaley M. GeertsmaAmanda BruceSteve M. CallaghanAlvin JoselinJulianna J. TomlinsonMichael G. SchlossmacherWilliam L. StanfordPatrik BrundinScott D. RyanMaxime W.C. Rousseaux.
  12. A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. Junsong Zhou, Yi Wu, Lubica Rauova, Gavin Koma, Lu Wang, Mortimer Poncz, Hong Li, Tong Liu, Karen P. Fong, Joel S. Bennett, Satya P. Kunapuli, David W. Essex; Blood 2022; 139 (13): 2050–2065.
  13. PBAF chromatin remodeler complexes that mediate meiotic transitions in mouse. Rodrigo O. de Castro, Luciana Previato de Almeida, Agustin Carbajal, Irma Gryniuk, Roberto J. Pezza; Development 15 September 2022; 149 (18): dev199967
  14. Primary and memory immune responses against rough Brucella canis are less robust compared to smooth B. abortus and B. melitensis following intratracheal infection in mice. Stranahan, Lauren W. and Garcia-Gonzalez, Daniel G. and Hensel, Martha E. and Arenas-Gamboa, Angela M., Frontiers in Immunology, 13, 2022 1664-3224
  15. Paternal alcohol exposures program intergenerational hormetic effects on offspring fetoplacental growth. Thomas, Kara N. and Zimmel, Katherine N. and Basel, Alison and Roach, Alexis N. and Mehta, Nicole A. and Thomas, Kelly R. and Dotson, Luke J. and Bedi, Yudhishtar S. and Golding, Michael C.,   Frontiers in Cell and Developmental Biology, 10, 2022, 2296-634x
  16. TBC1Domain Family Member 25 deficiency aggravates cerebral ischemia-reperfusion injury via TAK1-JNK/p38 pathway. Zhang, Z.Ma, T.Fu, Z.Feng, Y.Wang, Z.Tian, S.Liu, Z.Wei, W.Li, X.Chen, J., & Zhao, W. (2022).  Journal of Neurochemistry160392– 411
  17. Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice. Sams, K.L., Mukai, C., Marks, B.A. et al. Reprod Biol Endocrinol 20, 150 (2022)
  18. Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits. Dyson, JJAbbasi, FVaradkar, PMcCright, B. FASEB BioAdvances20224273– 282
  19. TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure. Maria Areli Lorenzana-Carrillo, Keshav Gopal, Nikole J. Byrne, Saymon Tejay, Bruno Saleme, Subhash K. Das, Yongneng Zhang, Alois Haromy, Farah Eaton, Michelle Mendiola Pla, Dawn E. Bowles, Jason R. B. Dyck, John R. Ussher, Evangelos D. Michelakis, Gopinath Sutendra. Science Translational Medicine, 2022, eabm3565, 14, 669
  20. In Utero Ultrafine Particulate Exposure Yields Sex- and Dose-Specific Responses to Neonatal Respiratory Syncytial Virus Infection. Carmen Lau, Jonathan C. Behlen, Alexandra Myers, Yixin Li, Jiayun Zhao, Navada Harvey, Gus Wright, Aline Rodrigues Hoffmann, Renyi Zhang, and Natalie M. Johnson. Environmental Science & Technology 2022 56 (16), 11527-11535
  21. Loss of C2 Domain Protein (C2CD5) Alters Hypothalamic Mitochondrial Trafficking, Structure, and Function. Gavini C, K, White C, R, Mansuy-Aubert V, Aubert G. Neuroendocrinology 2022;112:324-337
  22. CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate. Suzuki, T., Tatsukawa, T., Sudo, G. et al.  Sci Rep 12, 6505 (2022)
  23. Intratracheal inoculation results in Brucella-associated reproductive disease in male mouse and guinea pig models of infection. Hensel Martha E., Stranahan Lauren W., Edwards John F., Arenas-Gamboa Angela M. Frontiers in Microbiology, 13, 2022, 1664-302X
  24. Microcomputed tomography staging of bone histolysis in the regenerating mouse digit. Paulina D. Ketcham MS Felisha Imholt BS Mingquan Yan MS Hannah M. Smith BS Shabistan Asrar BS Ling Yu PhD Connor P. Dolan PhD Osama Qureshi MS Yu-Lieh Lin PhD Ian Xia BS Patrick C. Hall BS Alyssa R. Falck BS Kirby M. Sherman MS Dana Gaddy PhD Larry J. Suva PhD Ken Muneoka PhD Regina Brunauer PhD Lindsay A. Dawson PhD. Wound Rep Reg20221– 11
  25. Extracellular S100B inhibits A-type voltage-gated potassium currents and increases L-type voltage-gated calcium channel activity in dopaminergic neurons. Bancroft, E. A.De La Mora, M.Pandey, G.Zarate, S. M., & Srinivasan, R. (2022). Glia7012), 2330– 2347
  26. Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis. Torres-Odio S, Lei Y, Gispert S, Maletzko A, Key J, Menissy SS, Wittig I, Auburger G, West AP.  J Immunol. 2021 Apr 15;206(8):1890-1900
  27. Digit specific denervation does not inhibit mouse digit tip regeneration. Connor P. Dolan, Felisha Imholt, Mingquan Yan, Tae-Jung Yang, Joshua Gregory, Osama Qureshi, Katherine Zimmel, Kirby M. Sherman, Hannah M. Smith, Alyssa Falck, Eric Leininger, Ling Yu, Regina Brunauer, Larry J. Suva, Dana Gaddy, Lindsay A. Dawson, Ken Muneoka. Developmental Biology. Volume 486, 2022, Pages 71-80, ISSN 0012-1606
  28. Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome. Sajad Sofi, Louisa Williamson, Gabrielle L. Turvey, Charlotte Scoynes, Claire Hirst, Jonathan Godwin, Neil Brockdorff, Justin Ainscough, Dawn Coverley;  J Cell Biol 4 April 2022; 221 (4): e202103185
  29. NRF2-Dependent Placental Effects Vary by Sex and Dose following Gestational Exposure to Ultrafine Particles. Behlen, J.C.; Lau, C.H.; Pendleton, D.; Li, Y.; Hoffmann, A.R.; Golding, M.C.; Zhang, R.; Johnson, N.M. Antioxidants 202211, 352
  30. Magnetic Fields and Magnetically Stimulated Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Differentially Modulate L-Type Voltage-Gated Calcium Channel Activity in Midbrain Neurons. Muzhaozi Yuan, Eric A. Bancroft, Jingfan Chen, Rahul Srinivasan, and Ya Wang. ACS Applied Nano Materials 2022 5 (1), 205-215
  31. Epimorphic regeneration of the mouse digit tip is finite. Dolan, C.P., Yang, TJ., Zimmel, K. et al. . Stem Cell Res Ther 13, 62 (2022)
  32. Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome. Bedi, Y.S., Roach, A.N., Thomas, K.N. et al.  Epigenetics & Chromatin 15, 2 (2022)
  33. Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine. Ling Yu, Yu-Lieh Lin, Mingquan Yan, Tao Li, Emily Y. Wu, Katherine Zimmel, Osama Qureshi, Alyssa Falck, Kirby M. Sherman, Shannon S. Huggins, Daniel Osorio Hurtado, Larry J. Suva, Dana Gaddy, James Cai, Regina Brunauer, Lindsay A. Dawson, Ken Muneoka. Development 15 January 2022; 149 (2): dev200249
  34. Enhancing endocannabinoid signalling in astrocytes promotes recovery from traumatic brain injury. Mei Hu, Dexiao Zhu, Jian Zhang, Fei Gao, Jack Hashem, Philip Kingsley, Lawrence J Marnett, Ken Mackie, Chu Chen. Brain, 2022;, awab310
  35. Disrupted development and altered hormone signaling in male Padi2/Padi4 double knockout mice. Kelly L. Sams, Chinatsu Mukai, Brooke A. Marks, Chitvan Mittal, Elena Alina Demeter, Sophie Nelissen, Jennifer K. Grenier, Ann E. Tate, Faraz Ahmed, Scott A. Coonrod bioRxiv 2022.02.09.479603
  36. Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in brain phenotypes and unveils a new role for the major vault protein. Perrine F. Kretz, Christel Wagner, Charlotte Montillot, Sylvain Hugel, Ilaria Morella, Meghna Kannan, Anna Mikhaleva, Marie-Christine Fischer, Maxence Milhau, Riccardo Brambilla, Yann Herault, Alexandre Reymond, Mohammed Selloum, Stephan C. Collins, Binnaz Yalcin. bioRxiv 2022.01.23.477432
  37. PFTK1 kinase regulates axogenesis during development via RhoA activation. Yasmilde Rodríguez González, Fatemeh Kamkar, Paymaan Jafar-nejad, Suzi Wang, Dianbo Qu, Leticia Sanchez Alvarez, Dina Hawari, Margaret Sonnenfeld, Ruth S. Slack, Paul Albert, David S. Park, Alvin Joselin. bioRxiv 2022.01.11.475789
  38. Hmga2 deficiency is associated with allometric growth retardation, infertility, and behavioral abnormalities in mice. Mi Ok Lee, Jingyi Li, Brian W Davis, Srijana Upadhyay, Hadil M Al Muhisen, Larry J Suva, Tracy M Clement, Leif Andersson, G3 Genes|Genomes|Genetics, Volume 12, Issue 2, February 2022
  39. Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice. Longatti, A., Ponzoni, L., Moretto, E., Giansante, G., Lattuada, N., Colombo, M., Francolini, M., Sala, M., Murru, L., Passafaro, M. Mol Neurobiol 58, 6092–6110 (2021)
  40. Loss of mDia1 and Fhod1 impacts platelet formation but not platelet function. Zuidscherwoude, M., Haining, E., Simms, V., Watson, S., Grygielska, B., Hardy, A., Bacon, A., Watson, S., Thomas, S. Taylor & Francis. 0953-7104 (2021)
  41. SND1 promotes Th1/17 immunity against chlamydial lung infection through enhancing dendritic cell function. Wang X, Zhang C, Wang S, Rashu R, Thomas R, et al. (2021) PLOS Pathogens 17(2): e1009295.
  42. Exercise hormone irisin is a critical regulator of cognitive function. Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, Christie BR, Schmider AB, Soberman RJ, Besnard A, Jedrychowski MP, Kim H, Tu H, Kim E, Choi SH, Tanzi RE, Spiegelman BM, Wrann CD. Nat Metab. 2021 Aug;3(8):1058-1070. doi: 10.1038/s42255-021-00438-z. Epub 2021 Aug 20. Erratum in: Nat Metab. 2021 Oct;3(10):1432.
  43. Gestational Exposure to Ultrafine Particles Reveals Sex- and Dose-Specific Changes in Offspring Birth Outcomes, Placental Morphology, and Gene Networks. Jonathan C Behlen, Carmen H Lau, Yixin Li, Prit Dhagat, Jone A Stanley, Aline Rodrigues Hoffman, Michael C Golding, Renyi Zhang, Natalie M Johnson. Toxicological Sciences, 2021; 2021 Oct 5:kfab118. doi: 10.1093/toxsci/kfab118. Epub ahead of print. PMID: 34609516.
  44. Aging Delays Epimorphic Regeneration in Mice. Regina Brunauer, PhD, Ian G Xia, BS, Shabistan N Asrar, BS, Lindsay A Dawson, PhD, Connor P Dolan, PhD, Ken Muneoka, PhD,  The Journals of Gerontology: Series A, 2021;, glab131
  45. IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, Chouchani E, Ahmad R, Rosen ED.  J Clin Invest. 2021 Apr 1;131(7):e144888.
  46. Loss of TIMP4 (Tissue Inhibitor of Metalloproteinase 4) Promotes Atherosclerotic Plaque Deposition in the Abdominal Aorta Despite Suppressed Plasma Cholesterol Levels. Mei Hu, Sayantan Jana, Tolga Kilic, Faqi Wang, Mengcheng Shen, Gerrit Winkelaar, Gavin Y. Oudit, Katey Rayner, Da-wei Zhang, Zamaneh Kassiri. 1 Apr 2021. Arteriosclerosis, Thrombosis, and Vascular Biology. ;0:ATVBAHA.120.315522
  47. Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21. Ricardo Moure, Montserrat Cairó, Samantha Morón-Ros, Tania Quesada-López, Laura Campderrós, Rubén Cereijo, Alvaro Hernáez, Francesc Villarroya, and Marta Giralt. American Journal of Physiology-Endocrinology and Metabolism 2021 320:4, E822-E834
  48. Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis. Song Zhang, Satsuki Yamada, Sungjo Park, Aleksandr Klepinin, Tuuli Kaambre, Andre Terzic, Petras Dzeja. Biochemical and Biophysical Research Communications, Volume 546, 2021, Pages 59-64, ISSN 0006-291X,
  49. Extracellular S100B alters spontaneous Ca2+ fluxes in dopaminergic neurons via L-type voltage gated calcium channels: Implications for Parkinson’s disease. Eric A. Bancroft, Gauri Pandey, Sara M. Zarate, Rahul Srinivasan. bioRxiv 2021.02.24.432751
  50. Cytisine is neuroprotective in female but not male 6‐hydroxydopamine lesioned parkinsonian mice and acts in combination with 17‐β‐estradiol to inhibit apoptotic endoplasmic reticulum stress in dopaminergic neurons. Zarate, S.M., Pandey, G., Chilukuri, S., Garcia, J.A., Cude, B., Storey, S., Salem, N.A., Bancroft, E.A., Hook, M. and Srinivasan, R. (2021).  Journal of Neurochemistry. Accepted Author Manuscript
  51. A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol. Salem, Nihal A,  Mahnke, Amanda H, Tseng, Alexander M, Garcia, Cadianna R, Jahromi, Hooman K, Geoffroy, Cédric G, Miranda, Rajesh C. Neurotoxicology and Teratology. Volume 83,2021, 106943, ISSN 0892-0362
  52. Genetic deletion of Rnd3 suppresses apoptosis through NF‑κB signaling in the brain. Dong, H., Sun, Q., Zhang, Y., Li, Y., Yuan, F., Mao, S., Liu, B. Oncology Reports 45.2 (2020): 595-605
  53. Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility. Hayase, Y., Amano, S., Hashizume, K. et al. acta neuropathol commun 8, 206 (2020)
  54. Quantifying Spontaneous Ca2+ Fluxes and their Downstream Effects in Primary Mouse Midbrain Neurons. Bancroft, E. A., Srinivasan, R. J. Vis. Exp. (163), e61481, doi:10.3791/61481 (2020)
  55. Gestational exposure to particulate air pollution exacerbates the growth phenotypes induced by preconception paternal alcohol use: a multiplex model of exposure. Mustapha TA, Chang RC, Garcia-Rhodes D, Pendleton D, Johnson NM, Golding MC.. Environ Epigenet. 2020 Sep 27;6(1). eCollection 2020. PMID: 33214907
  56. Proximal digit tip amputation initiates simultaneous blastema and transient fibrosis formation and results in partial regeneration. Lindsay A. Dawson PhD, Paula P. Schanes MS, Luis Marrero PhD, Kathryn Jordan BS, Regina Brunauer PhD, Katherine N. Zimmel BS, Osama Qureshi MS, Felisha M. Imholt BA, Alyssa R. Falck BS, Mingquan Yan MS, Connor P. Dolan PhD, Ling Yu PhD, Ken Muneoka PhD. Wiley Online Library. 19 August 2020.
  57. In situ characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampus. Taylor E. Huntington, Rahul Srinivasan. bioRxiv 2020.06.21.163618;
  58. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D. Adri Chakraborty, Caroline K. Scogin, Kinza Rizwan, Thomas S. Morley and Joseph M. Rutkowski.  Front. Physiol., 22 April 2020
  59. TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway. Guo S, Liu Y, Gao L, et al. Int J Biol Sci. 2020;16(8):1335-1348. Published 2020 Feb 21. doi:10.7150/ijbs.41130
  60. Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. Chopra, D.G., Yiv, N., Hennings, T.G. et al. Sci Rep 10, 5629 (2020).
  61. Mid-Gestation lethality of Atxn2l-Ablated Mice. Jana Key, Patrick N. Harter, Nesli-Ece Sen, Elise Gradhand, Georg Auburger, and Suzana Gispert. Int. J. Mol. Sci. 2020, 21(14), 5124.
  62. ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice. Bi X, Kuwano T, Lee PC, Millar JS, Li L, Shen Y, Soccio RE, Hand NJ, Rader DJ.  Circ Res. 2020 Nov 6;127(11):1347-1361. doi: 10.1161/CIRCRESAHA.120.317175. Epub 2020 Sep 11. PMID: 32912065.
  63. Impaired Mitochondrial Stress Response due to CLPP Deletion Is Associated with Altered Mitochondrial Dynamics and Increased Apoptosis in Cumulus Cells. Esencan, E., Jiang, Z., Wang, T. et al. Reprod. Sci. 27, 621–630 (2020).
  64. Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration. Sung G. Ji, Yuliya V. Medvedeva, John H. Weiss. Experimental Neurology, Volume 325, 2020, 113161, ISSN 0014-4886
  65. Hypothalamic C2-domain protein involved in MC4R trafficking and control of energy balance. Chaitanya K. Gavini, Tyler M. Cook, David J. Rademacher, Virginie Mansuy-Aubert. Metabolism, Volume 102, 2020, 153990, ISSN 0026-0495
  66. Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation. Campderrós, L. , Moure, R. , Cairó, M. , Gavaldà‐Navarro, A. , Quesada‐López, T. , Cereijo, R. , Giralt, M. , Villarroya, J. and Villarroya, F. (2019). Obesity, 27: 1606-1616
  67. Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis. Liheng Shi, Min Zhao, Colette A. Abbey, Shu‐Huai Tsai, Wankun Xie, Dylan Pham, Samantha Chapman, Kayla J. Bayless, Travis W. Hein, Robert H. Rosa, Michael L. Ko, Lih Kuo, Gladys Y.‐P. Ko. 2019. Journal of the American Heart Association, e013673, 8, 22
  68. Hepatic Transcriptomics Reveals that Lipogenesis Is a Key Signaling Pathway in Isocitrate Dehydrogenase 2 Deficient Mice. Jeong Hoon Pan, Jingsi Tang, Mersady C. Redding, Kaleigh E. Beane, Cara L. Conner, Yun Jeong Cho, Jiangchao Zhao, Jun Ho Kim, Byungwhi C. Kong, Jin Hyup Lee, Jae Kyeom Kim Genes (Basel) 2019 Sep; 10(9): 728. Published online 2019 Sep 19. doi: 10.3390/genes10090728
  69. Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification. Dawson, L. A., Brunauer, R., Zimmel, K. N., Qureshi, O., Falck, A. R., Kim, P., Dolan, C. P., Yu, L., Lin, Y. L., Daniel, B., Yan, M., Muneoka, K. J. Vis. Exp. (149), e59749, doi:10.3791/59749 (2019).
  70. Characterization of Brucella canis infection in mice. Stranahan LW, Khalaf OH, Garcia-Gonzalez DG, Arenas-Gamboa AM (2019) PLOS ONE 14(6): e0218809
  71. Mitochondrial Protein Poldip2 Controls VSMC Differentiated Phenotype by O-Linked GlcNAc Transferase-Dependent Inhibition of a Ubiquitin Proteasome System. Felipe Paredes  and Holly C Williams  and Raymundo A Quintana  and Alejandra San Martin. Circulation Research
  72. Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. Margaret F Lippincott, Silvia León, Yee-Ming Chan, Chrysanthi Fergani, Rajae Talbi, I Sadaf Farooqi, Christopher M Jones, Wiebke Arlt, Susan E Stewart, Trevor R Cole, Ei Terasawa, Janet E Hall, Natalie D Shaw, Victor M Navarro, Stephanie Beth Seminara, The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 10, October 2019, Pages 4304–4318
  73. Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo. Sabrina Petralla , Luis Emiliano Peña-Altamira, Eleonora Poeta, Francesca Massenzio, Marco Virgili, Simona Nicole Barile, Luigi Sbano, Emanuela Profilo, Mariangela Corricelli, Alberto Danese, Carlotta Giorgi, Rita Ostan, Miriam Capri, Paolo Pinton, Ferdinando Palmieri, Francesco Massimo Lasorsa, and Barbara Monti. nt. J. Mol. Sci. 2019, 20(18), 4486
  74. Six‐Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia‐Reperfusion Injury by Suppressing Transforming Growth Factor‐β‐Activated Kinase 1. Guo, W. , Fang, H. , Cao, S. , Chen, S. , Li, J. , Shi, J. , Tang, H. , Zhang, Y. , Wen, P. , Zhang, J. , Wang, Z. , Shi, X. , Pang, C. , Yang, H. , Hu, B. and Zhang, S. (2019), Hepatology
  75. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM. Cell. 2018 Dec 13;175(7):1756-1768.e17. doi: 10.1016/j.cell.2018.10.025. Erratum in: Cell. 2019 Jul 11;178(2):507-508.
  76. Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain. Marina S. Hernandes and Bernard Lassègue and Lula Hilenski and Jonathan Adams and Ning Gao and Chia-Yi Kuan and Yu-Yo Sun and Lihong Cheng and Daniel Kikuchi and Manuel Yepes and Kathy K. Griendling. Hernandes et al. Journal of Neuroinflammation.  (2018) 15:45
  77. Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer’s disease by positive modulation of σ1 receptors. Tangui Maurice, Jean-Noël Volle, Manon Strehaiano, Lucie Crouzier, Claire Pereira, Nikolay Kaloyanov, David Virieux, Jean-Luc Pirat. Pharmacological Research, Volume 144, 2019, Pages 315-330, ISSN 1043-6618.
  78. Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass. Yeonhee Joo, Hyejin Kim, Sungjoong Lee, Soojin Lee. International Journal of Obesity, 2019, 1476-5497.
  79. Alterations in sperm-inherited noncoding RNAs associate with late-term fetal growth restriction induced by preconception paternal alcohol use. Yudhishtar Bedi, Richard C. Chang, Rachel Gibbs, Tracy M. Clement, Michael C. Golding. Reproductive Toxicology, Volume 87, 2019, Pages 11-20, ISSN 0890-6238.
  80. Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation. Niall Mortimer, Tatjana Ganster, Aet O’Leary, Sandy Popp, Florian Freudenberg, Andreas Reif, María Soler Artigas, Marta Ribasés, Josep Antoni Ramos-Quiroga, Klaus-Peter Lesch, Olga Rivero, Neuropharmacology, 2019, ISSN 0028-3908.
  81. Expression and distribution of Trophoblast Glycoprotein in the mouse retina. Colin M Wakeham, Gaoying Ren, Catherine W Morgans. bioRxiv  590216
  82. Identification of PKCα-dependent phosphoproteins in mouse retina. Colin M. Wakeham, Phillip A. Wilmarth, Jennifer M. Cunliffe, John E. Klimek, Gaoying Ren, Larry L. David, Catherine W. Morgans. bioRxiv  589184
  83. Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation. Jeremy D. Hill, Viviana Zuluaga-Ramirez, Sachin Gajghate, Malika Winfield, Uma Sriram, Slava Rom, Yuri Persidsky. Brain, Behavior, and Immunity, Volume 76, 2019, Pages 165-181, ISSN 0889-1591
  84. A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis. E. R. Hawken, C. P. Normandeau, J. Gardner Gregory, B. Cécyre, J.-F. Bouchard, K. Mackie & É. C. Dumont. Neuropsychopharmacology (2019)
  85. Smarcal1 and Zranb3 protect replication forks from Myc-induced DNA replication stress. Matthew V Puccetti, Clare M Adams, Saul Kushinsky and Christine M. Eischen. Cancer Res. January 4 2019 DOI: 10.1158/0008-5472.CAN-18-2705
  86. Poldip2 knockdown inhibits vascular smooth muscle proliferation and neointima formation by regulating the expression of PCNA and p21. Datla, S. R., L Hilenski, L., Seidel-Rogol, B., Dikalova, A. E., Harousseau, M., Punkova, L., … Griendling, K. K. (2018). Laboratory investigation; a journal of technical methods and pathology, 99(3), 387–398
  87. A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. Ros O, Barrecheguren PJ, Cotrufo T, Schaettin M, Roselló-Busquets C, et al. (2018) PLOS Genetics 14(6): e1007432.
  88. Long noncoding RNA Malat1 is not essential for T cell development and response to LCMV infection. Yingpeng Yao, Wenhui Guo, Jingjing Chen, Pingting Guo, Guotao Yu, Juanjuan Liu, Fang Wang, Jingjing Liu, Menghao You, Tianyan Zhao, Youmin Kang, Xi Ma & Shuyang Yu, 2018, RNA Biology, 15:12, 1477-1486
  89. Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer. Lijun Xue, Xiyong Liu, Qinchuan Wang, Charlie Q Liu, Yunru Chen, Wei Jia, Ronhong Hsie, Yifan Chen, Frank Luh, Shu Zheng, Yun Yen. Am J Transl Res 2018;10(11):3635-3649
  90. Axonal regrowth is impaired during digit tip regeneration in mice. Connor P. Dolan, Mingquan Yan, Katherine Zimmel, Tae-Jung Yang, Eric Leininger, Lindsay A. Dawson, Ken Muneoka, Developmental Biology, 2018, ISSN 0012-1606
  91. Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection. Luo H, Winkelmann ER, Zhu S, Ru W, Mays E, Silvas JA, Vollmer LL, Gao J, Peng BH, Bopp NE, Cromer C, Shan C, Xie G, Li G, Tesh R, Popov VL, Shi PY, Sun SC, Wu P, Klein RS, Tang SJ, Zhang W, Aguilar PV, Wang T. J Clin Invest. 2018 Sep 24. pii: 99902. doi: 10.1172/JCI99902. [Epub ahead of print]
  92. The mitochondrial calcium uniporter regulates procoagulant platelet formation. Kholmukhamedov, A. , Janecke, R. , Choo, H. and Jobe, S. M. (Sept 2018), J Thromb Haemost. Accepted Author Manuscript. . doi:10.1111/jth.14284
  93. Blastema formation and periosteal ossification in the regenerating adult mouse digit. Dawson, L. A., Schanes, P. P., Kim, P., Imholt, F. M., Qureshi, O., Dolan, C. P., Yu, L., Yan, M., Zimmel, K. N., Falck, A. R. and Muneoka, K. (August 2018), Wound Rep and Reg. Accepted Author Manuscript. . doi:10.1111/wrr.12666
  94. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Hill, J. D., Zuluaga‐Ramirez, V., Gajghate, S., Winfield, M., and Persidsky, Y. (2018) British Journal of Pharmacology, doi: 10.1111/bph.14387
  95. LMO7 deficiency reveals the significance of the cuticular plate for hearing function.  Ting-Ting Du, James B Dewey, Elizabeth L Wagner, Shimon P Francis, Edward Perez-Reyes, Wenhao Xu, John S Oghalai, Jung-Bum Shin. bioRxiv  334052
  96. Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. Sanjeev Kiran Gotru, Jesus Gil-Pulido, Niklas Beyersdorf, Andreas Diefenbach, Isabelle C. Becker, Timo Vögtle, Katharina Remer, Vladimir Chubanov, Thomas Gudermann, Heike M. Hermanns, Bernhard Nieswandt, Thomas Kerkau, Alma Zernecke, Attila Braun. The Journal of Immunology. April 15, 2018, 200  (8)  2529-2534;  DOI: 10.4049/jimmunol.1701467
  97. PER2 regulation of mammary gland development. C. M. McQueen, E. E. Schmitt, T. R. Sarkar, J. Elswood, R. P. Metz, D. Earnest, M. Rijnkels, W. W. Porter. Development 2018 : dev.157966 doi: 10.1242/dev.157966
  98. Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain. Marina S. Hernandes, Bernard Lassègue, Lula L. Hilenski, Jonathan Adams, Ning Gao, Chia-Yi Kuan, Yu-Yo Sun, Lihong Cheng, Daniel S. Kikuchi, Manuel Yepes and Kathy K. Griendling. Journal of Neuroinflammation 2018 15:
  99. Genotypic and phenotypic characterization of the Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove mouse model. Weihbrecht K, Goar WA, Carter CS, Sheffield VC, Seo S (2018) PLoS ONE 13(2): e0192755.
  100. Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V. J Psychopharmacol. 2018 Jan 1:269881117742100. doi: 10.1177/0269881117742100. [Epub ahead of print] PMID: 29364035
  101. Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain. Skariah, G., Seimetz, J., Norsworthy, M. et al. BMC Biol 15, 54 (2017)
  102. The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model. Janghorban M, Langer EM, Wang X, Zachman D, Daniel CJ, et al. (2017) PLOS ONE 12(11): e0188910. Request this line
  103. Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production. Elise Dalmas, Frank M. Lehmann, Erez Dror, Stephan Wueest, Constanze Thienel, Marcela Borsigova, Marc Stawiski, Emmanuel Traunecker, Fabrizio C. Lucchini, Dianne H. Dapito, Sandra M. Kallert, Bruno Guigas, Francois Pattou, Julie Kerr-Conte, Pierre Maechler, Jean-Philippe Girard, Daniel Konrad, Christian Wolfrum, Marianne Böni-Schnetzler, Daniela Finke, Marc Y. Donath, , Immunity, Volume 47, Issue 5, 2017 November 21, Pages 928-942.e7, ISSN 1074-7613. Request this line
  104. Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174. Yuji Shinjo, Kumiko Makide, Keita Satoh, Fumiya Fukami, Asuka Inoue, Kuniyuki Kano, Yuko Otani, Tomohiko Ohwada, Junken Aoki, Biochemical and Biophysical Research Communications, Volume 494, Issues 1–2, 2017 October 7, Pages 332-338, ISSN 0006-291X
  105. Thirst-associated preoptic neurons encode an aversive motivational drive. Allen WE, DeNardo LA, Chen MZ, Liu CD, Loh KM, Fenno LE, Ramakrishnan C, Deisseroth K, Luo L. Science 2017 Sep 15;357(6356):1149-1155. doi: 10.1126/science.aan6747. [Epub ahead of print]
  106. Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung. Guo H, Kazadaeva Y, Ortega FE, Manjunath N, Desai TJ. Dev Biol. 2017 Oct 1;430(1):214-223. doi: 10.1016/j.ydbio.2017.07.018. Epub 2017 Aug 12. Request this line
  107. SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection. Fino KK, Yang L, Silveyra P, Hu S, Umstead TM, DiAngelo S, Halstead ES, Cooper TK, Abraham T, Takahashi Y, Zhou Z, Wang HG, Chroneos ZC.Sci Rep. 2017 Aug 4;7(1):7262. doi: 10.1038/s41598-017-07724-5.PMID: 28779131
  108. Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome. Nycole A. Copping, Sarah G.B. Christian, Dylan J. Ritter, M. Saharul Islam, Nathalie Buscher, Dorota Zolkowska, Michael C. Pride, Elizabeth L. Berg, Janine M. LaSalle, Jacob Ellegood, Jason P. Lerch, Lawrence T. Reiter, Jill L. Silverman, Scott V. Dindot. Human Molecular Genetics. 19 July 2017. pii: 89281. doi: [Epub ahead of print] Request this line
  109. Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption. Sakamuri SSVP, Watts R, Takawale A, Wang X, Hernandez-Anzaldo S, Bahitham W, Fernandez-Patron C, Lehner R, Kassiri Z. Sci Rep. 2017 Jul 24;7(1):6210. doi: 10.1038/s41598-017-05951-4
  110. No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M. Sci Rep. 2017 Jun 29;7(1):4384. doi: 10.1038/s41598-017-04472-4. Request this line
  111. Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase. Serena Mezzar, Evelyn De Schryver, Stanny Asselberghs, Els Meyhi, Petruta L. Morvay, Myriam Baes, Paul P. Van Veldhoven, , Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids, Volume 1862, Issue 9, 2017 June 17, Pages 972-990, ISSN 1388-1981
  112. The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory.  Ridings-Figueroa, R., Stewart, E. R., Nesterova, T. B., Coker, H., Pintacuda, G., Godwin, J., … Coverley, D. (2017). Genes & Development, 31(9), 876–888
  113. An exercise in brain genoarchitectonics: Analysis of AZIN2-Lacz expressing neuronal populations in the mouse hindbrain. Martinez-de-la-Torre M, Lambertos A, Peñafiel R, Puelles L. J Neurosci Res. 2017 May 3. doi: 10.1002/jnr.24053. [Epub ahead of print] Request this line
  114. Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection. Serfass JM, Takahashi Y, Zhou Z, Kawasawa YI, Liu Y, Tsotakos N, Young MM, Tang Z, Yang L, Atkinson JM, Chroneos ZC, Wang HG. J Biol Chem. 2017 Jun 16;292(24):10097-10111. doi: 10.1074/jbc.M117.792747. Epub 2017 Apr 28.
  115. Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice.    Lawrence M. Carey, Tannia Gutierrez, Liting Deng, Wan-Hung Lee, Ken Mackie & Andrea G. Hohmann, Scientific Reports 7, Article number: 944 (2017)
  116. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. Ansa-Addo EA, Zhang Y, Yang Y, Hussey GS, Howley BV, Salem M, Riesenberg B, Sun S, Rockey DC, Karvar S, Howe PH, Liu B, Li Z. J Clin Invest. 2017 Mar 13. pii: 89281. doi: 10.1172/JCI89281. [Epub ahead of print] Request this line
  117. Intact colonic KCa1.1 channel activity in KCNMB2 knockout mice. Casper K. Larsen, Helle A. Praetorius, Jens Leipziger, Mads V. Sorensen. Physiological Reports. Published 13 March 2017 Vol. 5 no. e13179 DOI: 10.14814/phy2.13179
  118. Erythrocyte survival is controlled by microRNA-142. Rivkin N, Chapnik E, Mildner A, Barshtein G, Porat Z, Kartvelishvily E, Dadosh T, Birger Y, Amir G, Yedgar S, Izraeli S, Jung S, Hornstein E. Haematologica. 2016 Dec 1. pii: haematol.2016.156109. [Epub ahead of print]. Request this line
  119. Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase. Akbar Ahmad, Domokos Gerö, Gabor Olah, Csaba Szabo. Int J Mol Med. 2016 Dec; 38(6): 1683–1692. doi: 10.3892/ijmm.2016.2771
  120. CTNNA3 discordant regulation of nested LRRTM3. Zhiming Fang, Valsamma Eapen, Raymond A. Clarke. Meta Gene. 9 November 2016, ISSN 2214-5400, doi: 10.1016/j.mgene.2016.11.003. Request this line
  121. Loss of SynDIG1 reduces excitatory synapse maturation but not formation in vivo. George Chenaux, Lucas Matt, Travis C. Hill, Inderpreet Kaur, Xiao-Bo Liu, Lyndsey M. Kirk, David J. Speca, Samuel A. McMahon, Karen Zito, Johannes W. Hell, Elva Díaz. eneuro. Oct 2016, ENEURO.0130-16.2016; DOI: 10.1523/ENEURO.0130-16.2016. Request this line
  122. Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity. Abbott GW, Jepps TA. J Vasc Res. 2016 Oct 7;53(3-4):138-148
  123. Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain. Joanna M. Dragich, Takaaki Kuwajima, Megumi Hirose-Ikeda, Michael S. Yoon, Evelien Eenjes, Joan R. Bosco, Leora M. Fox, Alf H. Lystad, Tinmarla F. Oo, Olga Yarygina, Tomohiro Mita, Satoshi Waguri, Yoshinobu Ichimura, Masaaki Komatsu, Anne Simonsen,  Robert E. Burke, Carol A. Mason, and Ai Yamamoto.. eLife, 5, September 2016.
  124. A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response. Jandhyala DM, Wong J, Mantis NJ, Magun BE, Leong JM, Thorpe CM. Toxins (Basel) 2016 Sep 2;8(9). pii: E259. doi: 10.3390/toxins8090259. Request this line
  125. Disruption of calcitonin gene-related peptide signaling accelerates muscle denervation and dampens cytotoxic neuroinflammation in SOD1 mutant mice. Ringer C, Tune S, Bertoune MA, Schwarzbach H, Tsujikawa K, Weihe E, Schütz B. Cell Mol Life Sci. 2016 Aug 23. [Epub ahead of print]
  126. Two transgenic mouse models for beta subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Kacso G, Ravasz D, Doczi J, Nemeth B, Madgar O, Saada A, Ilin P, Miller C, Ostergaard E, Iordanov I, Adams D, Vargedo Z, Araki M, Araki K, Nakahara M, Ito H, Gal A, Molnar MJ, Nagy Z, Patocs A, Adam-Vizi V, Chinopoulos C. Biochem J. 2016 Aug 5. pii: BCJ20160594. [Epub ahead of print] Request this line
  127. OLA1, a translational regulator of p21, maintains optimal cell proliferation necessary for developmental progression. Ding Z, Liu Y, Rubio V, He J, Minze LJ, Shi ZZ. Mol Cell Biol. 2016 Aug 1. pii: MCB.00137-16. [Epub ahead of print]
  128. Collagen Fibril Ultrastructure in Mice Lacking Discoidin Domain Receptor 1. Tonniges JR, Albert B, Calomeni EP, Roy S, Lee J, Mo X, Cole SE, Agarwal G.Microsc Microanal. 2016 Jun;22(3):599-611. doi: 10.1017/S1431927616000787 [Epub ahead of print]
  129. A new model to study the role of arachidonic acid in colon cancer pathophysiology. Fan YY, Callaway E, Monk J, Goldsby JS, Yang P, Vincent L, Chapkin RS.Cancer Prev Res (Phila). 2016 Jun 23. pii: canprevres.0060.2016. [Epub ahead of print] Request this line
  130. Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet. Vanderperre B, Herzig S, Krznar P, Hörl M, Ammar Z, Montessuit S, Pierredon S, Zamboni N, Martinou JC. PLoS Genet. 2016 May 13;12(5):e1006056. doi: 10.1371/journal.pgen.1006056. eCollection 2016 May. [Epub ahead of print] Request this line
  131. Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis. Lange C, Mowat F, Sayed H, Mehad M, Duluc L, Piper S, Luhmann U, Nandi M, Kelly P, Smith A, Ali R, Leiper J, Bainbridge J. Exp Eye Res. 2016 May 12. pii: S0014-4835(16)30110-5. doi: 10.1016/j.exer.2016.05.007. [Epub ahead of print]
  132. Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Xiao J, Vemula SR, Xue Y, Khan MM, Kuruvilla KP, Marquez-Lona EM, Cobb MR, LeDoux MS. Exp Neurol. 2016 May 6. pii: S0014-4886(16)30119-4. doi: 10.1016/j.expneurol.2016.05.006. [Epub ahead of print] Request this line
  133. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A. J Neurosci. 2016 Apr 27;36(17):4681-9. doi: 10.1523/JNEUROSCI.2893-15.2016 Request this line
  134. Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo. Lee CS, Penberthy KK, Wheeler KM, Juncadella IJ, Vandenabeele P, Lysiak JJ, Ravichandran KS. Immunity 2016 Mar 28. pii: S1074-7613(16)30020-6. doi: 10.1016/j.immuni.2016.02.005. [Epub ahead of print]
  135. Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Ebrahim S, Avenarius MR, Grati M, Krey JF, Windsor AM, Sousa AD, Ballesteros A, Cui R, Millis BA, Salles FT, Baird MA, Davidson MW, Jones SM, Choi D, Dong L, Raval MH, Yengo CM, Barr-Gillespie PG, Kachar B. Nat Commun. 2016 Mar 1;7:10833. doi: 10.1038/ncomms10833.
  136. Patatin-like phospholipase domain-containing protein 3 is involved in hepatic fatty acid and triglyceride metabolism through X-box binding protein 1 and modulation of endoplasmic reticulum stress in mice. Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T. Hepatol Res. 2016 May;46(6):584-92. doi: 10.1111/hepr.12587. Epub 2016 Feb 2
  137. A new HIF-1α/RANTES driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF. Koh MY, Gagea M, Sargis T, Lemos R Jr, Grandjean G, Charbono A, Bekiaris V, Sedy J, Kiriakova G, Liu X, Roberts LR, Ware C, Powis G. Hepatology 2016 Jan 22. doi: 10.1002/hep.28468. [Epub ahead of print] Request this line
  138. Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z. Biol Reprod. 2016 Jan 13. pii: biolreprod.115.136358. [Epub ahead of print] Request this line
  139. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch-Grau M, Aghaie A, Perfettini I, Dupont T, Avan P, El-Amraoui A, Petit C. J Cell Biol. 2016 Jan 11. pii: jcb.201509017. [Epub ahead of print]
  140. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP. Nat Commun. 2015 Dec 21;6:8995. doi: 10.1038/ncomms9995. [Epub ahead of print]
  141. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Dvash E, Har-Tal M, Barak S, Meir O, Rubinstein M. Nat Commun. 2015 Dec 11;6:10112. doi: 10.1038/ncomms10112. [Epub ahead of print] Request this line
  142. Control of developmentally primed erythroid genes by combinatorial co-repressor actions. Stadhouders R, Cico A, Stephen T, Thongjuea S, Kolovos P, Baymaz HI, Yu X, Demmers J, Bezstarosti K, Maas A, Barroca V, Kockx C, Ozgur Z, van Ijcken W, Arcangeli ML, Andrieu-Soler C, Lenhard B, Grosveld F, Soler E. Nat Commun. 2015 Nov 23;6:8893. doi: 10.1038/ncomms9893. [Epub ahead of print]
  143. Role of GPR55 during Axon Growth and Target Innervation. Cherif H, Argaw A, Cécyre B, Bouchard A, Gagnon J, Javadi P, Desgent S, Mackie K, Bouchard JF. eNeuro. 2015 Nov 9;2(5). pii: ENEURO.0011-15.2015. doi: 10.1523/ENEURO.0011-15.2015.
  144. Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Kim Y, Kim SH, Kim KH, Chae S, Kim C, Kim J, Shin HS, Lee MS, Kim D Hum Mol Genet. 2015 Oct 3. pii: ddv417. [Epub ahead of print]
  145. Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner Hornsby AK, Redhead YT, Rees DJ, Ratcliff MS, Reichenbach A, Wells T, Francis L, Amstalden K, Andrews ZB, Davies JS. Psychoneuroendocrinology 2016 Jan;63:198-207. doi: 10.1016/j.psyneuen.2015.09.023. Epub 2015 Sep 25.
  146. MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, Seidman MM, Greenberg RA. Genes Dev. 2015 Sep 15;29(18):1955-68. doi: 10.1101/gad.264192.115. Epub 2015 Sep 3. PMID: 26338419; PMCID: PMC4579352.
  147. Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ. Yoon, J., Park, J., Conde, J., Wakamiya, M., Prakash, L., Prakash, S., Genes & Dev. 2015. 29: 2588-2602
  148. Kcne4 deletion sex and age specifically impairs cardiac repolarization in mice. Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW. FASEB J. 2015 Sep 23. pii: fj.15-278754. [Epub ahead of print]
  149. Vapb / Amyotrophic Lateral Sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response. Larroquette F, Seto L, Gaub PL, Kamal B, Wallis D, Larivière R, Vallée J, Robitaille R, Tsuda H. Hum Mol Genet. 2015 Sep 11. pii: ddv360. [Epub ahead of print] Request this line
  150. PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice. Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T. Hepatol Res. 2015 Sep 8. doi: 10.1111/hepr.12587. [Epub ahead of print] Request this line
  151. GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice. Lenhart KC, O’Neill TJ 4th, Cheng Z, Dee R, Demonbreun AR, Li J, Xiao X, McNally EM, Mack CP, Taylor JM. Skelet Muscle. 2015 Aug 21;5:27. doi: 10.1186/s13395-015-0054-6 Request this line
  152. Monoacylglycerol Lipase Regulates Fever Response. Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B. PLoS One. 2015 Aug 19;10(8):e0134437. doi: 10.1371/journal.pone.0134437. Request this line
  153. Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect. Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou JC. Mol Cell. 2015 Aug 6;59(3):491-501. doi: 10.1016/j.molcel.2015.06.035. Request this line
  154. Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Choi H, Han C, Jin S, Kwon JT, Kim J, Jeong J, Kim J, Ham S, Jeon S, Yoo YJ, Cho C. Biol Reprod. 2015 Aug 5. pii: biolreprod.115.130252. [Epub ahead of print]
  155. Rfx2 is required for spermatogenesis in the mouse. Shawlot W, Vazquez-Chantada M, Wallingford JB, Finnell RH. Genesis. 2015 Aug 6. doi: 10.1002/dvg.22880. [Epub ahead of print] Request this line
  156. Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Thakurdas SM, Lopez MF, Kakuda S, Fernandez-Valdivia R, Zarrin-Khameh N, Haltiwanger RS, Jafar-Nejad H. Hepatology. 2015 Aug 1. doi: 10.1002/hep.28024. [Epub ahead of print] Request this line
  157. Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid and energy homeostasis in mice. Hargett SR, Walker NN, Hussain SS, Hoehn KL, Keller SR. Am J Physiol Endocrinol Metab. 2015 May 26:ajpendo.00007.2015. doi: 10.1152/ajpendo.00007.2015. [Epub ahead of print] Request this line
  158. Metabolic epistasis among apoptosis-inducing factor and the mitochondrial import factor CHCHD4. Modjtahedi N, Hangen E, Gonin P, Kroemer G. Cell Cycle. 2015 Jul 15:1-5. [Epub ahead of print] Request this line
  159. Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses. Law M, Lee Y, Morales JL, Ning G, Huang W, Pabon J, Kannan AK, Jeong AR, Wood A, Carter C, Mohinta S, Song J, August A. J Immunol.. 2015 Jul 15;195(2):426-30. doi: 10.4049/jimmunol.1401442. Epub 2015 Jun 8. Request this line
  160. Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Lambden S, Kelly P, Ahmetaj-Shala B, Wang Z, Lee B, Nandi M, Torondel B, Delahaye M, Dowsett L, Piper S, Tomlinson J, Caplin B, Colman L, Boruc O, Slaviero A, Zhao L, Oliver E, Khadayate S, Singer M, Arrigoni F, Leiper J. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1382-92. doi: 10.1161/ATVBAHA.115.305278. Epub 2015 Apr 9.
  161. Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice. Yang AW, Sachs AJ, Nystuen AM. Neurogenetics. 2015 Jun 9. [Epub ahead of print]
  162. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, Bashir S, Ramakrishnan A, Leung E, Qia YH, Zhang N, Combes KR, Ketela T, Lin F, Houry WA, Aman A, Al-Awar R, Zheng W, Wienholds E, Xu CJ, Dick J, Wang JC, Moffat J, Minden MD, Eaves CJ, Bader GD, Hao Z, Kornblau SM, Raught B, Schimmer AD. Cancer Cell. 2015 Jun 8;27(6):864-76. doi: 10.1016/j.ccell.2015.05.004. Request this line
  163. A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy. Hu, G., McQuiston, T., Bernard, A. et al.. Nat Cell Biol 17, 930–942 (2015).
  164. Exacerbated Experimental Colitis in TNFAIP8-Deficient Mice. Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH. J Immunol. 2015 Jun 15;194(12):5736-42. doi: 10.4049/jimmunol.1401986. Epub 2015 May 6. Request this line
  165. miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis. Chapnik E, Rivkin N, Mildner A, Beck G, Pasvolsky R, Metzl-Raz E, Birger Y, Amir G, Tirosh I, Porat Z, Israel LL, Lellouche E, Michaeli S, Lellouche JP, Izraeli S, Jung S, Hornstein E. Elife. 2014 May 23;3:e01964. doi: 10.7554/eLife.01964. Request this line
  166. 3-Mercaptopyruvate sulfurtransferase deficient mice show accelerated glucose uptake and a dysregulated metabolic profile. Gero D, Ahmad A, Brunyanszki A, Olah G, Szczesny B, Szabo C. Nitric Oxide. 2015;47:S35–S36. doi: 10.1016/j.niox.2015.02.086.
  167. Enamel Hypomineralization and Structural Defects in Amelotin-deficient Mice. Nakayama Y, Holcroft J, Ganss B. J Dent Res. 2015 May;94(5):697-705. doi: 10.1177/0022034514566214. Epub 2015 Feb 24.
  168. MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Rozenova K, Jiang J, Donaghy R, Aressy B, Greenberg RA, Tong W. Blood. 2015 Mar 12;125(11):1730-8. doi: 10.1182/blood-2014-07-588145. Epub 2015 Jan 30. Request this line
  169. Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. True C, Nasrin Alam S, Cox K, Chan YM, Seminara SB. Endocrinology. 2015 Apr;156(4):1386-97. doi: 10.1210/en.2014-1862. Epub 2015 Jan 9.
  170. Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model. Martins C, Hůlková H, Dridi L, Dormoy-Raclet V, Grigoryeva L, Choi Y, Langford-Smith A, Wilkinson FL, Ohmi K, DiCristo G, Hamel E, Ausseil J, Cheillan D, Moreau A, Svobodová E, Hájková Z, Tesařová M, Hansíková H, Bigger BW, Hrebícek M, Pshezhetsky AV. Brain. 2015 Feb;138(Pt 2):336-55. doi: 10.1093/brain/awu355. Epub 2015 Jan 6. Request this line
  171. Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells. Krysiak K, Tibbitts JF, Shao J, Liu T, Ndonwi M, Walter MJ. Exp Hematol.. 2015 Apr;43(4):319-30.e10. doi: 10.1016/j.exphem.2014.12.005. Epub 2014 Dec 27. Request this line
  172. A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction. Patra K, Lyons DJ, Bauer P, Hilscher MM, Sharma S, Leão RN, Kullander K. Eur J Neurosci. 2015 Feb;41(3):316-27. doi: 10.1111/ejn.12790. Epub 2014 Nov 20.
  173. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G, Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XH, Chang J. Circ Res. 2015 Jan 2;116(1):e1-e10. doi: 10.1161/CIRCRESAHA.116.304940. Epub 2014 Oct 27. Request this line
  174. Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling. Airik R, Slaats GG, Guo Z, Weiss AC, Khan N, Ghosh A, Hurd TW, Bekker-Jensen S, Schrøder JM, Elledge SJ, Andersen JS, Kispert A, Castelli M, Boletta A, Giles RH, Hildebrandt F. J Am Soc Nephrol. 2014 Nov;25(11):2573-83. doi: 10.1681/ASN.2013050565. Epub 2014 Apr 10. Request this line
  175. SLO3 K+ channels control calcium entry through CATSPER channels in sperm. Chávez JC, Ferreira JJ, Butler A, De La Vega Beltrán JL, Treviño CL, Darszon A, Salkoff L, Santi CM. J Biol Chem. 2014 Nov 14;289(46):32266-75. doi: 10.1074/jbc.M114.607556. Epub 2014 Sep 30.
  176. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Matz A, Lee SJ, Schwedhelm-Domeyer N, Zanini D, Holubowska A, Kannan M, Farnworth M, Jahn O, Göpfert MC, Stegmüller J. Cell Death Differ. 2015 Apr;22(4):626-42. doi: 10.1038/cdd.2014.163. Epub 2014 Oct 24. Request this line
  177. CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects. Youngblood BA, MacDonald CC. Stem Cell Res. 2014 Nov;13(3 Pt A):413-21. doi: 10.1016/j.scr.2014.09.005. Epub 2014 Sep 28. Request this line
  178. Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton. Khazaei MR, Girouard MP, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW, Brouhard G, Cloutier JF, Fournier AE. J Biol Chem. 2014 Oct 24;289(43):30133-43. doi: 10.1074/jbc.M114.570440. Epub 2014 Sep 15.
  179. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Xiong X, Zhao Y, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, Sun Y. Elife. 2014 Aug 21;3:e02236. doi: 10.7554/eLife.02236. Request this line
  180. Lack of angiopoietin-like-2 expression limits the metabolic stress induced by a high-fat diet and maintains endothelial function in mice. Yu C, Luo X, Farhat N, Daneault C, Duquette N, Martel C, Lambert J, Thorin-Trescases N, Rosiers CD, Thorin E. J Am Heart Assoc. 2014 Aug 15;3(4). pii: e001024. doi: 10.1161/JAHA.114.001024. Request this line
  181. Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model. Ehrhardt N, Bedoya C, Péterfy M. Nutr Metab (Lond). 2014 Aug 16;11:37. doi: 10.1186/1743-7075-11-37. eCollection 2014.
  182. Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. Szabo R, Peters DE, Kosa P, Camerer E, Bugge TH. PLoS Genet. 2014 Jul 31;10(7):e1004470. doi: 10.1371/journal.pgen.1004470. eCollection 2014 Jul.
  183. GRAF1 promotes ferlin-dependent myoblast fusion. Lenhart KC, Becherer AL, Li J, Xiao X, McNally EM, Mack CP, Taylor JM. Dev Biol. 2014 Sep 15;393(2):298-311. doi: 10.1016/j.ydbio.2014.06.025. Epub 2014 Jul 11. Request this line
  184. ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity. Quirós PM, Español Y, Acín-Pérez R, Rodríguez F, Bárcena C, Watanabe K, Calvo E, Loureiro M, Fernández-García MS, Fueyo A, Vázquez J, Enríquez JA, López-Otín C. Cell Rep. 2014 Jul 24;8(2):542-56. doi: 10.1016/j.celrep.2014.06.018. Epub 2014 Jul 10.
  185. CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3′ end processing. Youngblood BA, Grozdanov PN, MacDonald CC. Nucleic Acids Res. 2014 Jul;42(13):8330-42. doi: 10.1093/nar/gku551. Epub 2014 Jun 23. Request this line
  186. Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Honda S, Arakawa S, Nishida Y, Yamaguchi H, Ishii E, Shimizu S. Nat Commun. 2014 Jun 4;5:4004. doi: 10.1038/ncomms5004.
  187. Enhanced fear expression in Spir-1 actin organizer mutant mice. Pleiser S, Banchaabouchi MA, Samol-Wolf A, Farley D, Welz T, Wellbourne-Wood J, Gehring I, Linkner J, Faix J, Riemenschneider MJ, Dietrich S, Kerkhoff E. Eur J Cell Biol.. 2014 May-Jun;93(5-6):225-37. doi: 10.1016/j.ejcb.2013.11.001. Request this line
  188. F-spondin deficient mice have a high bone mass phenotype. Palmer GD, Attur MG, Yang Q, Liu J, Moon P, Beier F, Abramson SB. PLoS One. 2014 May 29;9(5):e98388. doi: 10.1371/journal.pone.0098388. eCollection 2014.
  189. The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity. Peters DE, Szabo R, Friis S, Shylo NA, Uzzun Sales K, Holmbeck K, Bugge TH. J Biol Chem. 2014 May 23;289(21):14740-9. doi: 10.1074/jbc.M113.541318. Epub 2014 Apr 4.
  190. Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4. Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, Wang X, Oudit GY, Kassiri Z. Circ Heart Fail. 2014 Jul;7(4):652-62. doi: 10.1161/CIRCHEARTFAILURE.114.001113. Epub 2014 May 19.
  191. LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy. Mull A, Kim G, Holaska JM. Muscle Nerve. 2015 Feb;51(2):222-8. doi: 10.1002/mus.24286. Epub 2014 Nov 19. Request this line
  192. Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts. Brown DI, Lassègue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK. PLoS One. 2014 May 5;9(5):e96657. doi: 10.1371/journal.pone.0096657. eCollection 2014. Request this line
  193. A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. Goriki A, Hatanaka F, Myung J, Kim JK, Yoritaka T, Tanoue S, Abe T, Kiyonari H, Fujimoto K, Kato Y, Todo T, Matsubara A, Forger D, Takumi T. PLoS Biol. 2014 Apr 15;12(4):e1001839. doi: 10.1371/journal.pbio.1001839. eCollection 2014 Apr. Request this line
  194. Adjuvant-specific regulation of long-term antibody responses by ZBTB20. Wang Y, Bhattacharya D. J Exp Med. 2014 May 5;211(5):841-56. doi: 10.1084/jem.20131821. Epub 2014 Apr 7. Request this line
  195. Impact of genetic background on neonatal lethality of Gga2 gene-trap mice. Doray B, Govero J, Kornfeld S. G3 (Bethesda). 2014 Mar 17;4(5):885-90. doi: 10.1534/g3.114.010355. Request this line
  196. Generation of a cre recombinase-conditional Nos1ap over-expression transgenic mouse. Auer DR, Sysa-Shah P, Bedja D, Simmers JL, Pak E, Dutra A, Cohn R, Gabrielson KL, Chakravarti A, Kapoor A. Biotechnol Lett. 2014 Jun;36(6):1179-85. doi: 10.1007/s10529-014-1473-x. Epub 2014 Feb 22.
  197. Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. Wei Q, Sha Y, Bhattacharya A, Abdel Fattah E, Bonilla D, Jyothula SS, Pandit L, Khurana Hershey GK, Eissa NT.Am J Respir Crit Care Med.. 2014 Jan 1;189(1):16-29. doi: 10.1164/rccm.201305-0874OC.
  198. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Chiang HS, Zhao Y, Song JH, Liu S, Wang N, Terhorst C, Sharpe AH, Basavappa M, Jeffrey KL, Reinecker HC. Nat Immunol. 2014 Jan;15(1):63-71. doi: 10.1038/ni.2766. Epub 2013 Nov 24.
  199. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, Fergusson MM, Rovira II, Allen M, Springer DA, Aponte AM, Gucek M, Balaban RS, Murphy E, Finkel T. Nat Cell Biol. 2013 Dec;15(12):1464-72. doi: 10.1038/ncb2868. Epub 2013 Nov 10. Request this line
  200. Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability. Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA. PLoS One. 2013 Oct 29;8(10):e76973. doi: 10.1371/journal.pone.0076973. eCollection 2013.
  201. Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. Guiraldelli MF, Eyster C, Wilkerson JL, Dresser ME, Pezza RJ. PLoS Genet. 2013 Mar;9(3):e1003383. doi: 10.1371/journal.pgen.1003383. Epub 2013 Mar 21. Request this line
  202. CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Namba T, Tian F, Chu K, Hwang SY, Yoon KW, Byun S, Hiraki M, Mandinova A, Lee SW. Cell Rep. 2013 Oct 31;5(2):331-9. doi: 10.1016/j.celrep.2013.09.020. Epub 2013 Oct 17. Request this line
  203. Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis. Sisay S, Pryce G, Jackson SJ, Tanner C, Ross RA, Michael GJ, Selwood DL, Giovannoni G, Baker D. PLoS One. 2013 Oct 9;8(10):e76907. doi: 10.1371/journal.pone.0076907. eCollection 2013.
  204. Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis. Martínez-Uña M, Varela-Rey M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martínez-Arranz I, García-Rodríguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martínez-Chantar ML, Aspichueta P, Mato JM. Hepatology. 2013 Oct;58(4):1296-305. doi: 10.1002/hep.26399. Epub 2013 Aug 14.
  205. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, Nishitani AM, Yu WM, Goodrich LV. PLoS Genet. 2013;9(9):e1003824. doi: 10.1371/journal.pgen.1003824. Epub 2013 Sep 26. Request this line
  206. Serum TRPM1 autoantibodies from melanoma associated retinopathy patients enter retinal on-bipolar cells and attenuate the electroretinogram in mice. Xiong WH, Duvoisin RM, Adamus G, Jeffrey BG, Gellman C, Morgans CW. PLoS One. 2013 Aug 1;8(8):e69506. doi: 10.1371/journal.pone.0069506. Print 2013.
  207. Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors. Gispert S, Parganlija D, Klinkenberg M, Dröse S, Wittig I, Mittelbronn M, Grzmil P, Koob S, Hamann A, Walter M, Büchel F, Adler T, Hrabé de Angelis M, Busch DH, Zell A, Reichert AS, Brandt U, Osiewacz HD, Jendrach M, Auburger G. Hum Mol Genet. 2013 Dec 15;22(24):4871-87. doi: 10.1093/hmg/ddt338. Epub 2013 Jul 12. Request this line
  208. Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes. López-Garcia C, Ramos-Molina B, Lambertos A, López-Contreras AJ, Cremades A, Peñafiel R. PLoS One. 2013 Jul 12;8(7):e69188. doi: 10.1371/journal.pone.0069188. Print 2013. Request this line
  209. Polymerase delta interacting protein 2 sustains vascular structure and function. Sutliff RL, Hilenski LL, Amanso AM, Parastatidis I, Dikalova AE, Hansen L, Datla SR, Long JS, El-Ali AM, Joseph G, Gleason RL Jr, Taylor WR, Hart CM, Griendling KK, Lassègue B. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2154-61. doi: 10.1161/ATVBAHA.113.301913. Epub 2013 Jul 3. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):e132. Request this line
  210. TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension. Basu R, Lee J, Morton JS, Takawale A, Fan D, Kandalam V, Wang X, Davidge ST, Kassiri Z. Cardiovasc Res. 2013 Jun 1;98(3):360-71. doi: 10.1093/cvr/cvt067. Epub 2013 Mar 21.
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  213. A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. Li K, Fichna J, Schicho R, Saur D, Bashashati M, Mackie K, Li Y, Zimmer A, Göke B, Sharkey KA, Storr M. Neuropharmacology. 2013 Aug;71:255-63. doi: 10.1016/j.neuropharm.2013.03.029. Epub 2013 Apr 18.
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  217. Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH. PLoS Genet. 2012;8(8):e1002937. doi: 10.1371/journal.pgen.1002937. Epub 2012 Aug 30.
  218. Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. Borkham-Kamphorst E, Zimmermann HW, Gassler N, Bissels U, Bosio A, Tacke F, Weiskirchen R, Kanse SM. J Hepatol. 2013 Jan;58(1):104-11. doi: 10.1016/j.jhep.2012.09.007. Epub 2012 Sep 16. Erratum in: J Hepatol. 2014 Oct;61(4):967.
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  221. CLP36 is a negative regulator of glycoprotein VI signaling in platelets. Gupta S, Braun A, Morowski M, Premsler T, Bender M, Nagy Z, Sickmann A, Hermanns HM, Bösl M, Nieswandt B. Circ Res. 2012 Nov 9;111(11):1410-20. doi: 10.1161/CIRCRESAHA.112.264754. Epub 2012 Sep 5. Request this line
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  223. Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes. Nordstrand LM, Furu K, Paulsen J, Rognes T, Klungland A. Nucleic Acids Res. 2012 Nov;40(21):10950-63. doi: 10.1093/nar/gks839. Epub 2012 Sep 10. Request this line
  224. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ. Circ Res. 2012 Mar 16;110(6):818-30. doi: 10.1161/CIRCRESAHA.111.259663. Epub 2012 Feb 16. Request this line
  225. Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. van Gisbergen KP, Kragten NA, Hertoghs KM, Wensveen FM, Jonjic S, Hamann J, Nolte MA, van Lier RA. Nat Immunol. 2012 Sep;13(9):864-71. doi: 10.1038/ni.2393. Epub 2012 Aug 12. Request this line
  226. G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. Giguère PM, Billard MJ, Laroche G, Buckley BK, Timoshchenko RG, McGinnis MW, Esserman D, Foreman O, Liu P, Siderovski DP, Tarrant TK. Mol Immunol. 2013 Jun;54(2):193-8. doi: 10.1016/j.molimm.2012.12.001. Epub 2012 Dec 29.
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  229. Alanine-Glyoxylate Aminotransferase-2 Metabolizes Endogenous Methylarginines, Regulates NO, and Controls Blood Pressure. Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahey M, Salama A; The International Consortium for Blood Pressure Genome-Wide Association Studies, Wheeler DC, Leiper J. Arterioscler Thromb Vasc Biol. 2012 Sep 27.
  230. The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants. Zelano J, Mikulovic S, Patra K, Kühnemund M, Larhammar M, Emilsson L, Leao R, Kullander K. Exp Neurol. 2012 Sep 26.
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  239. Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice. Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. J Physiol. 2012 Jan 23.
  240. FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription. De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA, Di Ilio C, Melino G, Sette C, De Laurenzi V. Oncogene. 2012 Feb 2;31(5):573-82.
  241. Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin. Lizak M, Yarovinsky TO. Cell Host Microbe. Cell Host Microbe.2012 Jan 19;11(1):70-80.
  242. Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice. Kempster SL, Belteki G, Licence D, Charnock-Jones DS, Smith GC.Am J Physiol Endocrinol Metab. 2012 Jan;302(1)
  243. Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis. Welsh KJ, Lewis CT, Boyd S, Braun MC, Actor JK. Clin Dev Immunol. 2012;2012:429675
  244. Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants. Villard V, Meunier J, Chevallier N, Maurice T. J Pharmacol Sci. 2011;115(3):279-92.
  245. The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons. Bachy I, Franck MC, Li L, Abdo H, Pattyn A, Ernfors P. Dev Biol. 2011 Dec 1;360(1):77-86.
  246. Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation. Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF. Science. 2011 Nov 11;334(6057):809-13.
  247. Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM Jr. Hypertension. 2011 Oct;58(4):672-8.
  248. Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C. Immunity 2011 Oct 28;35(4):611-21
  249. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC. Nat Immunol. 2011 Aug 28;12(10):1002-9.
  250. Behavioural phenotyping of knockout mice for the sigma-1 (σ₁) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations. Chevallier N, Keller E, Maurice T. J Psychopharmacol. 2011 Jul;25(7):960-75.
  251. Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG. Islets. 2011 May-Jun;3(3):121-8.
  252. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD. Science. 2011 May 6;332(6030):717-21.
  253. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H. Development. 2011 May;138(10):1925-34.
  254. Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B. J. Biol. Chem. 2011 Apr 8;286(14):12271-82.
  255. Traumatic brain injury in mice lacking the K channel, TREK-1. Namiranian K, Brink CD, Goodman JC, Robertson CS, Bryan RM Jr. J Cereb Blood Flow Metab. 2011 Mar;31(3):e1-6.
  256. Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase. Martina Griesberger, Alexander Kollau, Gerald Wölkart, M. Verena Wenzl, Matteo Beretta, Michael Russwurm, Doris Koesling, Kurt Schmidt, Antonius C. F. Gorren, and Bernd Mayer. Mol. Pharmacol. 2011 Mar; 79(3):541-8.
  257. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Liu J, Gao BB, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP. Nat Med. 2011 Feb;17(2):206-10.
  258. RGS6/Gbeta5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Posokhova E, Wydeven N, Allen KL, Wickman K, Martemyanov KA. Circ Res. 2010 Nov 26;107(11):1350-4.
  259. RGS6, a modulator of parasympathetic activation in heart. Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, Li J, Stewart A, Swaminathan PD, Ibeawuchi SR, Shepherd A, Chen CK, Kutschke W, Mohler PJ, Mohapatra DP, Anderson ME, Fisher RA. Circ Res. 2010 Nov 26;107(11):1345-9
  260. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice. Hermanstyne TO, Kihira Y, Misono K, Deitchler A, Yanagawa Y, Misonou H. J Comp Neurol. 2010 Nov 1;518(21):4298-310.
  261. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. Inflamm Bowel Dis. 2011 Aug;17(8):1651-64.
  262. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF. Nat Neurosci. 2010 Sep;13(9):1113-9.
  263. Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Wu CS, Zhu J, Wager-Miller J, Wang S, O’Leary D, Monory K, Lutz B, Mackie K, Lu HC. Eur J Neurosci. 2010 Sep;32(5):693-706
  264. Transient Receptor Potential Melastatin 6 Knockout Mice Are Lethal whereas Heterozygous Deletion Results in Mild Hypomagnesemia. Woudenberg-Vrenken TE, Sukinta A, van der Kemp AW, Bindels RJ, Hoenderop JG. Nephron Physiol. 2010 Sep 1;117(2):p11-p19.
  265. IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50. Conner JR, Smirnova II, Moseman AP, Poltorak A. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11477-82.
  266. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S. Cell Metab. 2010 Apr 7;11(4):311-9.
  267. Characterization of murine SIRT3 transcript variants and corresponding protein products. Yang Y, Hubbard BP, Sinclair DA, Tong Q. J Cell Biochem. 2010 Nov 1;111(4):1051-8.
  268. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ, Bryan RM Jr. Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R461-9.
  269. The SLO3 sperm-specific potassium channel plays a vital role in male fertility. Santi CM, Martínez-López P, de la Vega-Beltrán JL, Butler A, Alisio A, Darszon A, Salkoff L. FEBS Lett. 2010 Mar 5;584(5):1041-6.
  270. Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, Lee E, Gao J, Bredemeyer AL, Helmink BA, Zavadil J, Sleckman BP, Palomero T, Ferrando A, Aifantis I. Nat Immunol. 2010 Mar;11(3):207-15.
  271. RGS7 and -11 Complexes Accelerate the ON-Bipolar Cell Light Response. Jianmei Zhang, Brett G. Jeffrey, Catherine W. Morgans, Neal S. Burke, Tammie L. Haley, Robert M. Duvoisin, and R. Lane Brown. Invest. Ophthalmol. Vis. Sci. 2010 Feb;51(2):1121-9.
  272. DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke W. Tu, X. Xu, L. Peng, X. Zhong, W. Zhang, M. Soundarapandian, C. Balel, M. Wang, N. Jia, W. Zhang, et al. Cell. 2010 Jan 22; 140(2): 222-234.
  273. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Cimen H, Han MJ, Yang Y, Tong Q, Koc H, Koc EC. Biochemistry. 2010 Jan 19;49(2):304-11.
  274. NAD<+>-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. J Biol Chem. 2010 Mar 5;285(10):7417-29.
  275. TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Morgans CW, Zhang J, Jeffrey BG, Nelson SM, Burke NS, Duvoisin RM, Brown RL. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19174-8.
  276. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL 3rd, Goodyear LJ, Tong Q. Aging (Albany NY). 2009 Aug 15;1(9):771-83.
  277. MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN. J Biol Chem. 2009 Feb 27;284(9):5986-93.

TIGM Mice Cited in Patents
  1. USE OF COMPOUNDS ACTIVATING SIRT-3 FOR MIMICKING EXERCISE. David A. Sinclair et al. United States Patent Application Publication. Application number: 12/739,428, Publication number: US 2011/0082189 A1 Filing date: Oct 23, 2008
  2. CLONED TRANSMEMBRANE RECEPTOR FOR 24-HYDROXYLATED VITAMIN D COMPOUNDS AND USES THEREOF. Rene St-Arnaud. US Patent Application 2012/0180142 Filing date: Nov 29, 2011
  3. COMPOSITIONS RELATING TO A PHOSPHOPROTEIN AND METHODS OF USE. US Patent Application 20120204273 Filing date: December 22, 2011. Published on August 9, 2012.
  4. CANCER TREATMENT TARGETING NON-CODING RNA OVEREXPRESSION. Stephen Safe, KyoungHyun Kim. United States Patent Application 20130267575. Filing Date: 03/07/2013; Publication Date: 10/10/2013.
  5. METHODS FOR DIAGNOSING AND TREATING LEARNING OR MENTAL DISORDERS Zakharenko, Stanislav S., Earls, Laurie R. United States Patent Application 20150005365. Filing Date: 02/01/2013, Publication Date: 01/01/2015
  6. METHODS AND COMPOSITIONS FOR INHIBITING GLYOXALASE 1 (GLO1) Palmer, Abraham, Distler, Margaret. United States Patent Application 20160038559 Publication Date: 02/11/2016 Filing Date: 03/12/2014

Publications by TIGM Scientists
  1. An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript. Dindot SV, Christian S, Murphy WJ, Berent A, Panagoulias J, Schlafer A, Ballard J, Radeva K, Robinson R, Myers L, Jepp T, Shaheen H, Hillman P, Konganti K, Hillhouse A, Bredemeyer KR, Black L, Douville J; FIRE consortium; FIRE Consortium.  Sci Transl Med. 2023 Mar 22;15(688):eabf4077. doi: 10.1126/scitranslmed.abf4077. Epub 2023 Mar 22. PMID: 36947593.
  2. Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice. Jingshu Chen, Shu Tang, Sui Ke, James J. Cai, Daniel Osorio, Andrei Golovko, Benjamin Morpurgo, Shaodong Guo, Yuxiang Sun, Melanie Winkle, George A. Calin, Yanan Tian,
    Redox Biology, Volume 54, 2022, 102377, ISSN 2213-2317
  3. Nutrient-Sensing Ghrelin Receptor in Macrophages Modulates Bisphenol A-Induced Intestinal Inflammation in Mice. Ye X, Liu Z, Han HW, Noh JY, Shen Z, Kim DM, Wang H, Guo H, Ballard J, Golovko A, Morpurgo B,  and Sun Y.  Genes. 2023; 14(7):1455.  doi: 10.3390/genes14071455
  4. Consistent Production of Mice with Conditional Knockout Alleles by CRISPR/Cas9-Mediated Genome Editing Using Two Guides/Two Oligos Approach. Golovko, A.,  Adams, J., Guo, H., Ballard, J., Gonzales, A., Morpurgo, B., Cytology and Genetics, 2020, January 01, 10.3103/S0095452720010065
  5. Sex as a Biological Variable is Evident Following Deletion of Intestinal Apolipoprotein A1. Tara Price, John Adams, Johnathan Ballard, Huiping Guo, Andrei Golovko, Ben Morpurgo, and Rosemary Walzem. Circulation, 140, A15657-A15657 (2019)
  6. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros, John Adams Jr, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K. Batra, Marie-Claude Beauchamp, Kathleen A. Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Wesley Chan, Hanying Chen, Ruby Dawson, Victoria DeMambro, Jinke D’Hont, Katharine M. Dibb, James D. Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya R. Guntur, Huiping Guo, Donald W. Harms, Anne Harrington, Kathryn E. Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B. Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie A. Jerome-Majewska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P. Ponnusamy, David Ray, Ronald J. Redder, Clifford J. Rosen, Nikki Ross, Mark T. Ruhe, Larisa Ryzhova, Ane M. Salvador, Sabrina Shameen Alam, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew W. Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J. Willis, Christian S. Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J. Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D. Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R. Thompson, K. C. Kent Lloyd, Joshua A. Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M. Miano & Gaetan Burgio. Genome Biology, volume 20, Article number: 171 (2019), doi:10.1186/s13059-019-1776-2
  7. Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology. Channabasavaiah Gurumurthy, Rolen Quadros, John Adams Jr., Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K Batra, Marie-Claude Beauchamp, Kathleen A Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Ruby Dawson, Victoria DeMambro, Jinke D’Hont, Katharine Dibb, James D Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya Guntur, Huiping Guo, Donald W Harms, Anne Harrington, Kathryn E Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie Jerome-Majeweska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P Ponnusamy, David Ray, Ronald J Redder, Clifford J Rosen, Nikki Ross, Mark T Ruhe, Larisa Ryzhova, Ane M Salvador, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J Willis, Christian S Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R Thompson, KC. Kent Lloyd, Joshua A Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M Miano, Gaetan Burgio; bioRxiv 393231;
  8. A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals. Chen, J., Zhong, L., Wu, J., Ke, S., Morpurgo, B., Golovko, A., Ouyang, N., Sun, Y., Guo, S., Tian, Y.  J. Vis. Exp. (136), e57327, doi:10.3791/57327 (2018)
  9. Long noncoding RNA MALAT1 regulates generation of reactive oxygen species and the insulin responses in male mice. J. Chen, S. Ke, L. Zhong, J. Wu, A. Tseng, B. Morpurgo, A. Golovko, G. Wang, J.J. Cai, X. Ma, D. Li, Y. Tian. Biochemical Pharmacology (2018), Volume 152, 2018, Pages 94-103, doi:
  10. Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. Cheng Y, Imanirad P, Jutooru I, Hedrick E, Jin UH, Rodrigues Hoffman A, Leal de Araujo J, Morpurgo B, Golovko A, Safe S. PLoS One. 2018 Feb 1;13(2):e0192264. doi: 10.1371/journal.pone.0192264. eCollection 2018.
  11. Sodium-dependent organic anion transporter (Slc10a6-/-) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate. Bakhaus K, Bennien J, Fietz D, Sánchez-Guijo A, Hartmann M, Serafini R, Love CC, Golovko A, Wudy SA, Bergmann M, Geyer J.J Steroid Biochem Mol Biol. 2017 Jul 22. pii: S0960-0760(17)30184-X. doi: 10.1016/j.jsbmb.2017.07.019 [Epub ahead of print]
  12. Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage. Hongmei Cui, Xinsheng Gu, Jingshu Chen, Ying Xie, Sui Ke, Jing Wu, Andrei Golovko, Benjamin Morpurgo, Chunhong Yan, Timothy D. Phillips, Wen Xie, Jianyuan Luo, Zhijun Zhou, Yanan Tian. Toxicology Letters. 18 April 2017. [Epub ahead of print]
  13. Absence of Malat1 does not prevent DEN-induced hepatocarcinoma in mice. Miard, S., Girard, M., Joubert, P., Carter, S., Gonzales, A., Guo, H., Morpurgo, B., Boivin, L., Golovko, A., Picard, F. Oncology Reports. 2017 [Epub ahead of print] Request this line
  14. The eIF2A knockout mouse.. Golovko A, Kojukhov A, Guan BJ, Morpurgo B, Merrick WC, Mazumder B, Hatzoglou M, Komar AA. Cell Cycle. 2016 Sep 29:0. [Epub ahead of print] Request this line
  15. Nuclear receptor 4A (NR4A) family – orphans no more.. Safe S, Jin UH, Morpurgo B, Abudayyeh A, Singh M, Tjalkens RB. J Steroid Biochem Mol Biol. 2015 Apr 23. pii: S0960-0760(15)00113-2.
  16. Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes. Loesch K, Galaviz S, Hamoui Z, Clanton R, Akabani G, Deveau M, DeJesus M, Ioerger T, Sacchettini JC, Wallis D. PLoS One. 2015 Apr 8;10(4):e0120534. doi: 10.1371/journal.pone.0120534
  17. Propitious Modulation Fibroblast Quiescence Mediated by Cytokine Expression Mediated from Embryonic Stem Cells.. Shane R, Golovko A, Morpurgo B, Dillberger A, Bonn T, Buz-Zard A. E-Journal of Age Management Medicine. October 2012,.Vol. 7, No 10.
  18. The mammalian gene function resource: the international knockout mouse consortium. . Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Kent Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Francis Stewart A, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. Mamm Genome.2012 Oct;23(9-10):580-6.
  19. Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction. Wallis D, Hill DS, Mendez IA, Abbott LC, Finnell RH, Wellman PJ, Setlow B. Brain Research. 2012 May 7.
  20. Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway.. Boyles AL, Ballard JL, Gorman EB, McConnaughey DR, Cabrera RM, Wilcox AJ, Lie RT, Finnell RH. Hum Reprod.2011 Aug;26(8):2232-8.
  21. A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Salojin KV, Cabrera RM, Sun W, Chang WC, Lin C, Duncan L, Platt KA, Read R, Vogel P, Liu Q, Finnell RH, Oravecz T. Blood. 2011 May 5;117(18):4895-904.
  22. Fuz Controls the Morphogenesis and Differentiation of Hair Follicles through the Formation of Primary Cilia. Daisy Dai, Huiping Zhu, Bogdan Wlodarczyk, Lei Zhang, Li Li, Allen G. Li4, Richard H. Finnell, Dennis R. Roop and Jiang Chen. Journal of Investigative Dermatology 2011 Feb;131(2):302-10.
  23. Fuz regulates craniofacial development through tissue specific responses to signaling factors. Zhang Z, Wlodarczyk BJ, Niederreither K, Venugopalan S, Florez S, Finnell RH, Amendt BA. PLoS One. 2011;6(9)
  24. Teratogenic effects of antiepileptic drugs. Hill DS, Wlodarczyk BJ, Palacios AM, Finnell RH. Expert Rev Neurother. 2010 Jun;10(6):943-59.
  25. Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. Iskandar BJ, Rizk E, Meier B, Hariharan N, Bottiglieri T, Finnell RH, Jarrard DF, Banerjee RV, Skene JH, Nelson A, Patel N, Gherasim C, Simon K, Cook TD, Hogan KJ. J Clin Invest. 2010 May 3;120(5):1603-16.

    Also see commentary:
    Neuronal injury: folate to the rescue? Kronenberg G, Endres M.I. J Clin Invest. 2010 May 3;120(5):1383-6.

  26. High-affinity folate receptor in cardiac neural crest migration: a gene knockdown model using siRNA. Rosenquist TH, Chaudoin T, Finnell RH, Bennett GD. Dev Dyn. 2010 Apr;239(4):1136-44.
  27. Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark. Bille C, Pedersen DA, Andersen AM, Mansilla MA, Murray JC, Christensen K, Ballard JL, Gorman EB, Cabrera RM, Finnell RH. Pediatr Res. 2010 Mar;67(3):274-9.
  28. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Gray RS, Abitua PB, Wlodarczyk BJ, Szabo-Rogers HL, Blanchard O, Lee I, Weiss GS, Liu KJ, Marcotte EM, Wallingford JB, Finnell RH. Nat Cell Biol. 2009 Oct;11(10):1225-32.
  29. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.Jakubowski H, Perla-Kaján J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. FASEB J. 2009 Jun;23(6):1721-7.
  30. Polymorphisms in the neural nicotinic acetylcholine receptor α4 subunit (CHRNA4) are associated with ADHD in a genetic isolate. Wallis D, Arcos-Burgos M, Jain M, Castellanos FX, Palacio JD, Pineda D, Lopera F, Stanescu H, Pineda D, Berg K, Palacio LG, Bailey-Wilson JE, Muenke M. Atten Defic Hyperact Disord. 2009 May;1(1):19-24
  31. Folate Transport and Folate Responsive Developmental Disorders. Gorman EB, Wallis D, Ballard JL, Goin-Kochel RP, Finnell RH. Pteridines. 2009, Vol. 20, Special issue, pp. 156-162.
  32. Review: Genetics of attention deficit/hyperactivity disorder. Wallis D, Russell HF, Muenke M. J Pediatr Psychol. 2008 Nov-Dec;33(10):1085-99
  33. Autoantibodies to folate receptor during pregnancy and neural tube defect risk. Cabrera RM, Shaw GM, Ballard JL, Carmichael SL, Yang W, Lammer EJ, Finnell RH. J Reprod Immunol. 2008 Oct;79(1):85-92.
  34. Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Wong RL, Wlodarczyk BJ, Min KS., Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP and Finnell RH. Hum. Mol. Genet. 2008 Feb 15; 17(4):587-601.

Publication describing our library and technology
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A. Genome Res. 2008 Oct;18(10):1670-9.

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