Publications

Publications Using TIGM Resources

 

  1. Thirst-associated preoptic neurons encode an aversive motivational drive. Allen WE, DeNardo LA, Chen MZ, Liu CD, Loh KM, Fenno LE, Ramakrishnan C, Deisseroth K, Luo L. Science 2017 Sep 15;357(6356):1149-1155. doi: 10.1126/science.aan6747. [Epub ahead of print]
  2. Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome. Nycole A. Copping, Sarah G.B. Christian, Dylan J. Ritter, M. Saharul Islam, Nathalie Buscher, Dorota Zolkowska, Michael C. Pride, Elizabeth L. Berg, Janine M. LaSalle, Jacob Ellegood, Jason P. Lerch, Lawrence T. Reiter, Jill L. Silverman, Scott V. Dindot. Human Molecular Genetics. 19 July 2017. pii: 89281. doi: doi.org/10.1093/hmg/ddx289. [Epub ahead of print] Request this line
  3. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. Ansa-Addo EA, Zhang Y, Yang Y, Hussey GS, Howley BV, Salem M, Riesenberg B, Sun S, Rockey DC, Karvar S, Howe PH, Liu B, Li Z. J Clin Invest. 2017 Mar 13. pii: 89281. doi: 10.1172/JCI89281. [Epub ahead of print] Request this line
  4. Intact colonic KCa1.1 channel activity in KCNMB2 knockout mice. Casper K. Larsen, Helle A. Praetorius, Jens Leipziger, Mads V. Sorensen. Physiological Reports. Published 13 March 2017 Vol. 5 no. e13179 DOI: 10.14814/phy2.13179
  5. Erythrocyte survival is controlled by microRNA-142. Rivkin N, Chapnik E, Mildner A, Barshtein G, Porat Z, Kartvelishvily E, Dadosh T, Birger Y, Amir G, Yedgar S, Izraeli S, Jung S, Hornstein E. Haematologica. 2016 Dec 1. pii: haematol.2016.156109. [Epub ahead of print]. Request this line
  6. CTNNA3 discordant regulation of nested LRRTM3. Zhiming Fang, Valsamma Eapen, Raymond A. Clarke. Meta Gene. 9 November 2016, ISSN 2214-5400, doi: 10.1016/j.mgene.2016.11.003. Request this line
  7. Loss of SynDIG1 reduces excitatory synapse maturation but not formation in vivo. George Chenaux, Lucas Matt, Travis C. Hill, Inderpreet Kaur, Xiao-Bo Liu, Lyndsey M. Kirk, David J. Speca, Samuel A. McMahon, Karen Zito, Johannes W. Hell, Elva Díaz. eneuro. Oct 2016, ENEURO.0130-16.2016; DOI: 10.1523/ENEURO.0130-16.2016. Request this line
  8. Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity. Abbott GW, Jepps TA. J Vasc Res. 2016 Oct 7;53(3-4):138-148
  9. A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response. Jandhyala DM, Wong J, Mantis NJ, Magun BE, Leong JM, Thorpe CM. Toxins (Basel) 2016 Sep 2;8(9). pii: E259. doi: 10.3390/toxins8090259. Request this line
  10. Disruption of calcitonin gene-related peptide signaling accelerates muscle denervation and dampens cytotoxic neuroinflammation in SOD1 mutant mice. Ringer C, Tune S, Bertoune MA, Schwarzbach H, Tsujikawa K, Weihe E, Schütz B. Cell Mol Life Sci. 2016 Aug 23. [Epub ahead of print]
  11. Two transgenic mouse models for beta subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Kacso G, Ravasz D, Doczi J, Nemeth B, Madgar O, Saada A, Ilin P, Miller C, Ostergaard E, Iordanov I, Adams D, Vargedo Z, Araki M, Araki K, Nakahara M, Ito H, Gal A, Molnar MJ, Nagy Z, Patocs A, Adam-Vizi V, Chinopoulos C. Biochem J. 2016 Aug 5. pii: BCJ20160594. [Epub ahead of print] Request this line
  12. OLA1, a translational regulator of p21, maintains optimal cell proliferation necessary for developmental progression. Ding Z, Liu Y, Rubio V, He J, Minze LJ, Shi ZZ. Mol Cell Biol. 2016 Aug 1. pii: MCB.00137-16. [Epub ahead of print]
  13. Collagen Fibril Ultrastructure in Mice Lacking Discoidin Domain Receptor 1. Tonniges JR, Albert B, Calomeni EP, Roy S, Lee J, Mo X, Cole SE, Agarwal G.Microsc Microanal. 2016 Jun;22(3):599-611. doi: 10.1017/S1431927616000787 [Epub ahead of print]
  14. A new model to study the role of arachidonic acid in colon cancer pathophysiology. Fan YY, Callaway E, Monk J, Goldsby JS, Yang P, Vincent L, Chapkin RS.Cancer Prev Res (Phila). 2016 Jun 23. pii: canprevres.0060.2016. [Epub ahead of print] Request this line
  15. Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet. Vanderperre B, Herzig S, Krznar P, Hörl M, Ammar Z, Montessuit S, Pierredon S, Zamboni N, Martinou JC. PLoS Genet. 2016 May 13;12(5):e1006056. doi: 10.1371/journal.pgen.1006056. eCollection 2016 May. [Epub ahead of print] Request this line
  16. Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis. Lange C, Mowat F, Sayed H, Mehad M, Duluc L, Piper S, Luhmann U, Nandi M, Kelly P, Smith A, Ali R, Leiper J, Bainbridge J. Exp Eye Res. 2016 May 12. pii: S0014-4835(16)30110-5. doi: 10.1016/j.exer.2016.05.007. [Epub ahead of print]
  17. Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Xiao J, Vemula SR, Xue Y, Khan MM, Kuruvilla KP, Marquez-Lona EM, Cobb MR, LeDoux MS. Exp Neurol. 2016 May 6. pii: S0014-4886(16)30119-4. doi: 10.1016/j.expneurol.2016.05.006. [Epub ahead of print] Request this line
  18. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A. J Neurosci. 2016 Apr 27;36(17):4681-9. doi: 10.1523/JNEUROSCI.2893-15.2016 Request this line
  19. Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo. Lee CS, Penberthy KK, Wheeler KM, Juncadella IJ, Vandenabeele P, Lysiak JJ, Ravichandran KS. Immunity 2016 Mar 28. pii: S1074-7613(16)30020-6. doi: 10.1016/j.immuni.2016.02.005. [Epub ahead of print]
  20. Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Ebrahim S, Avenarius MR, Grati M, Krey JF, Windsor AM, Sousa AD, Ballesteros A, Cui R, Millis BA, Salles FT, Baird MA, Davidson MW, Jones SM, Choi D, Dong L, Raval MH, Yengo CM, Barr-Gillespie PG, Kachar B. Nat Commun. 2016 Mar 1;7:10833. doi: 10.1038/ncomms10833.
  21. A new HIF-1α/RANTES driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF. Koh MY, Gagea M, Sargis T, Lemos R Jr, Grandjean G, Charbono A, Bekiaris V, Sedy J, Kiriakova G, Liu X, Roberts LR, Ware C, Powis G. Hepatology 2016 Jan 22. doi: 10.1002/hep.28468. [Epub ahead of print] Request this line
  22. Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z. Biol Reprod. 2016 Jan 13. pii: biolreprod.115.136358. [Epub ahead of print] Request this line
  23. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch-Grau M, Aghaie A, Perfettini I, Dupont T, Avan P, El-Amraoui A, Petit C. J Cell Biol. 2016 Jan 11. pii: jcb.201509017. [Epub ahead of print]
  24. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP. Nat Commun. 2015 Dec 21;6:8995. doi: 10.1038/ncomms9995. [Epub ahead of print]
  25. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Dvash E, Har-Tal M, Barak S, Meir O, Rubinstein M. Nat Commun. 2015 Dec 11;6:10112. doi: 10.1038/ncomms10112. [Epub ahead of print] Request this line
  26. Control of developmentally primed erythroid genes by combinatorial co-repressor actions. Stadhouders R, Cico A, Stephen T, Thongjuea S, Kolovos P, Baymaz HI, Yu X, Demmers J, Bezstarosti K, Maas A, Barroca V, Kockx C, Ozgur Z, van Ijcken W, Arcangeli ML, Andrieu-Soler C, Lenhard B, Grosveld F, Soler E. Nat Commun. 2015 Nov 23;6:8893. doi: 10.1038/ncomms9893. [Epub ahead of print]
  27. Role of GPR55 during Axon Growth and Target Innervation. Cherif H, Argaw A, Cécyre B, Bouchard A, Gagnon J, Javadi P, Desgent S, Mackie K, Bouchard JF. eNeuro. 2015 Nov 9;2(5). pii: ENEURO.0011-15.2015. doi: 10.1523/ENEURO.0011-15.2015.
  28. Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Kim Y, Kim SH, Kim KH, Chae S, Kim C, Kim J, Shin HS, Lee MS, Kim D Hum Mol Genet. 2015 Oct 3. pii: ddv417. [Epub ahead of print]
  29. Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner Hornsby AK, Redhead YT, Rees DJ, Ratcliff MS, Reichenbach A, Wells T, Francis L, Amstalden K, Andrews ZB, Davies JS. Psychoneuroendocrinology 2016 Jan;63:198-207. doi: 10.1016/j.psyneuen.2015.09.023. Epub 2015 Sep 25.
  30. Kcne4 deletion sex and age specifically impairs cardiac repolarization in mice. Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW. FASEB J. 2015 Sep 23. pii: fj.15-278754. [Epub ahead of print]
  31. Vapb / Amyotrophic Lateral Sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response. Larroquette F, Seto L, Gaub PL, Kamal B, Wallis D, Larivière R, Vallée J, Robitaille R, Tsuda H. Hum Mol Genet. 2015 Sep 11. pii: ddv360. [Epub ahead of print] Request this line
  32. PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice. Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T. Hepatol Res. 2015 Sep 8. doi: 10.1111/hepr.12587. [Epub ahead of print] Request this line
  33. GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice. Lenhart KC, O’Neill TJ 4th, Cheng Z, Dee R, Demonbreun AR, Li J, Xiao X, McNally EM, Mack CP, Taylor JM. Skelet Muscle. 2015 Aug 21;5:27. doi: 10.1186/s13395-015-0054-6 Request this line
  34. Monoacylglycerol Lipase Regulates Fever Response. Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B. PLoS One. 2015 Aug 19;10(8):e0134437. doi: 10.1371/journal.pone.0134437. Request this line
  35. Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect. Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou JC. Mol Cell. 2015 Aug 6;59(3):491-501. doi: 10.1016/j.molcel.2015.06.035. Request this line
  36. Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Choi H, Han C, Jin S, Kwon JT, Kim J, Jeong J, Kim J, Ham S, Jeon S, Yoo YJ, Cho C. Biol Reprod. 2015 Aug 5. pii: biolreprod.115.130252. [Epub ahead of print]
  37. Rfx2 is required for spermatogenesis in the mouse. Shawlot W, Vazquez-Chantada M, Wallingford JB, Finnell RH. Genesis. 2015 Aug 6. doi: 10.1002/dvg.22880. [Epub ahead of print] Request this line
  38. Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Thakurdas SM, Lopez MF, Kakuda S, Fernandez-Valdivia R, Zarrin-Khameh N, Haltiwanger RS, Jafar-Nejad H. Hepatology. 2015 Aug 1. doi: 10.1002/hep.28024. [Epub ahead of print] Request this line
  39. Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid and energy homeostasis in mice. Hargett SR, Walker NN, Hussain SS, Hoehn KL, Keller SR. Am J Physiol Endocrinol Metab. 2015 May 26:ajpendo.00007.2015. doi: 10.1152/ajpendo.00007.2015. [Epub ahead of print] Request this line
  40. Metabolic epistasis among apoptosis-inducing factor and the mitochondrial import factor CHCHD4. Modjtahedi N, Hangen E, Gonin P, Kroemer G. Cell Cycle. 2015 Jul 15:1-5. [Epub ahead of print] Request this line
  41. Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses. Law M, Lee Y, Morales JL, Ning G, Huang W, Pabon J, Kannan AK, Jeong AR, Wood A, Carter C, Mohinta S, Song J, August A. J Immunol.. 2015 Jul 15;195(2):426-30. doi: 10.4049/jimmunol.1401442. Epub 2015 Jun 8. Request this line
  42. Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Lambden S, Kelly P, Ahmetaj-Shala B, Wang Z, Lee B, Nandi M, Torondel B, Delahaye M, Dowsett L, Piper S, Tomlinson J, Caplin B, Colman L, Boruc O, Slaviero A, Zhao L, Oliver E, Khadayate S, Singer M, Arrigoni F, Leiper J. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1382-92. doi: 10.1161/ATVBAHA.115.305278. Epub 2015 Apr 9.
  43. Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice. Yang AW, Sachs AJ, Nystuen AM. Neurogenetics. 2015 Jun 9. [Epub ahead of print]
  44. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, Bashir S, Ramakrishnan A, Leung E, Qia YH, Zhang N, Combes KR, Ketela T, Lin F, Houry WA, Aman A, Al-Awar R, Zheng W, Wienholds E, Xu CJ, Dick J, Wang JC, Moffat J, Minden MD, Eaves CJ, Bader GD, Hao Z, Kornblau SM, Raught B, Schimmer AD. Cancer Cell. 2015 Jun 8;27(6):864-76. doi: 10.1016/j.ccell.2015.05.004. Request this line
  45. Exacerbated Experimental Colitis in TNFAIP8-Deficient Mice. Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH. J Immunol. 2015 Jun 15;194(12):5736-42. doi: 10.4049/jimmunol.1401986. Epub 2015 May 6. Request this line
  46. miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis. Chapnik E, Rivkin N, Mildner A, Beck G, Pasvolsky R, Metzl-Raz E, Birger Y, Amir G, Tirosh I, Porat Z, Israel LL, Lellouche E, Michaeli S, Lellouche JP, Izraeli S, Jung S, Hornstein E. Elife. 2014 May 23;3:e01964. doi: 10.7554/eLife.01964. Request this line
  47. Enamel Hypomineralization and Structural Defects in Amelotin-deficient Mice. Nakayama Y, Holcroft J, Ganss B. J Dent Res. 2015 May;94(5):697-705. doi: 10.1177/0022034514566214. Epub 2015 Feb 24.
  48. MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Rozenova K, Jiang J, Donaghy R, Aressy B, Greenberg RA, Tong W. Blood. 2015 Mar 12;125(11):1730-8. doi: 10.1182/blood-2014-07-588145. Epub 2015 Jan 30. Request this line
  49. Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. True C, Nasrin Alam S, Cox K, Chan YM, Seminara SB. Endocrinology. 2015 Apr;156(4):1386-97. doi: 10.1210/en.2014-1862. Epub 2015 Jan 9.
  50. Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model. Martins C, Hůlková H, Dridi L, Dormoy-Raclet V, Grigoryeva L, Choi Y, Langford-Smith A, Wilkinson FL, Ohmi K, DiCristo G, Hamel E, Ausseil J, Cheillan D, Moreau A, Svobodová E, Hájková Z, Tesařová M, Hansíková H, Bigger BW, Hrebícek M, Pshezhetsky AV. Brain. 2015 Feb;138(Pt 2):336-55. doi: 10.1093/brain/awu355. Epub 2015 Jan 6. Request this line
  51. Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells. Krysiak K, Tibbitts JF, Shao J, Liu T, Ndonwi M, Walter MJ. Exp Hematol.. 2015 Apr;43(4):319-30.e10. doi: 10.1016/j.exphem.2014.12.005. Epub 2014 Dec 27. Request this line
  52. A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction. Patra K, Lyons DJ, Bauer P, Hilscher MM, Sharma S, Leão RN, Kullander K. Eur J Neurosci. 2015 Feb;41(3):316-27. doi: 10.1111/ejn.12790. Epub 2014 Nov 20.
  53. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G, Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XH, Chang J. Circ Res. 2015 Jan 2;116(1):e1-e10. doi: 10.1161/CIRCRESAHA.116.304940. Epub 2014 Oct 27. Request this line
  54. Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling. Airik R, Slaats GG, Guo Z, Weiss AC, Khan N, Ghosh A, Hurd TW, Bekker-Jensen S, Schrøder JM, Elledge SJ, Andersen JS, Kispert A, Castelli M, Boletta A, Giles RH, Hildebrandt F. J Am Soc Nephrol. 2014 Nov;25(11):2573-83. doi: 10.1681/ASN.2013050565. Epub 2014 Apr 10. Request this line
  55. SLO3 K+ channels control calcium entry through CATSPER channels in sperm. Chávez JC, Ferreira JJ, Butler A, De La Vega Beltrán JL, Treviño CL, Darszon A, Salkoff L, Santi CM. J Biol Chem. 2014 Nov 14;289(46):32266-75. doi: 10.1074/jbc.M114.607556. Epub 2014 Sep 30.
  56. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Matz A, Lee SJ, Schwedhelm-Domeyer N, Zanini D, Holubowska A, Kannan M, Farnworth M, Jahn O, Göpfert MC, Stegmüller J. Cell Death Differ. 2015 Apr;22(4):626-42. doi: 10.1038/cdd.2014.163. Epub 2014 Oct 24. Request this line
  57. CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects. Youngblood BA, MacDonald CC. Stem Cell Res. 2014 Nov;13(3 Pt A):413-21. doi: 10.1016/j.scr.2014.09.005. Epub 2014 Sep 28. Request this line
  58. Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton. Khazaei MR, Girouard MP, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW, Brouhard G, Cloutier JF, Fournier AE. J Biol Chem. 2014 Oct 24;289(43):30133-43. doi: 10.1074/jbc.M114.570440. Epub 2014 Sep 15.
  59. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Xiong X, Zhao Y, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, Sun Y. Elife. 2014 Aug 21;3:e02236. doi: 10.7554/eLife.02236. Request this line
  60. Lack of angiopoietin-like-2 expression limits the metabolic stress induced by a high-fat diet and maintains endothelial function in mice. Yu C, Luo X, Farhat N, Daneault C, Duquette N, Martel C, Lambert J, Thorin-Trescases N, Rosiers CD, Thorin E. J Am Heart Assoc. 2014 Aug 15;3(4). pii: e001024. doi: 10.1161/JAHA.114.001024. Request this line
  61. Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model. Ehrhardt N, Bedoya C, Péterfy M. Nutr Metab (Lond). 2014 Aug 16;11:37. doi: 10.1186/1743-7075-11-37. eCollection 2014.
  62. Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. Szabo R, Peters DE, Kosa P, Camerer E, Bugge TH. PLoS Genet. 2014 Jul 31;10(7):e1004470. doi: 10.1371/journal.pgen.1004470. eCollection 2014 Jul.
  63. GRAF1 promotes ferlin-dependent myoblast fusion. Lenhart KC, Becherer AL, Li J, Xiao X, McNally EM, Mack CP, Taylor JM. Dev Biol. 2014 Sep 15;393(2):298-311. doi: 10.1016/j.ydbio.2014.06.025. Epub 2014 Jul 11. Request this line
  64. ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity. Quirós PM, Español Y, Acín-Pérez R, Rodríguez F, Bárcena C, Watanabe K, Calvo E, Loureiro M, Fernández-García MS, Fueyo A, Vázquez J, Enríquez JA, López-Otín C. Cell Rep. 2014 Jul 24;8(2):542-56. doi: 10.1016/j.celrep.2014.06.018. Epub 2014 Jul 10.
  65. CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3′ end processing. Youngblood BA, Grozdanov PN, MacDonald CC. Nucleic Acids Res. 2014 Jul;42(13):8330-42. doi: 10.1093/nar/gku551. Epub 2014 Jun 23. Request this line
  66. Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Honda S, Arakawa S, Nishida Y, Yamaguchi H, Ishii E, Shimizu S. Nat Commun. 2014 Jun 4;5:4004. doi: 10.1038/ncomms5004.
  67. Enhanced fear expression in Spir-1 actin organizer mutant mice. Pleiser S, Banchaabouchi MA, Samol-Wolf A, Farley D, Welz T, Wellbourne-Wood J, Gehring I, Linkner J, Faix J, Riemenschneider MJ, Dietrich S, Kerkhoff E. Eur J Cell Biol.. 2014 May-Jun;93(5-6):225-37. doi: 10.1016/j.ejcb.2013.11.001. Request this line
  68. F-spondin deficient mice have a high bone mass phenotype. Palmer GD, Attur MG, Yang Q, Liu J, Moon P, Beier F, Abramson SB. PLoS One. 2014 May 29;9(5):e98388. doi: 10.1371/journal.pone.0098388. eCollection 2014.
  69. The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity. Peters DE, Szabo R, Friis S, Shylo NA, Uzzun Sales K, Holmbeck K, Bugge TH. J Biol Chem. 2014 May 23;289(21):14740-9. doi: 10.1074/jbc.M113.541318. Epub 2014 Apr 4.
  70. Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4. Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, Wang X, Oudit GY, Kassiri Z. Circ Heart Fail. 2014 Jul;7(4):652-62. doi: 10.1161/CIRCHEARTFAILURE.114.001113. Epub 2014 May 19.
  71. LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy. Mull A, Kim G, Holaska JM. Muscle Nerve. 2015 Feb;51(2):222-8. doi: 10.1002/mus.24286. Epub 2014 Nov 19. Request this line
  72. Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts. Brown DI, Lassègue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK. PLoS One. 2014 May 5;9(5):e96657. doi: 10.1371/journal.pone.0096657. eCollection 2014. Request this line
  73. A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. Goriki A, Hatanaka F, Myung J, Kim JK, Yoritaka T, Tanoue S, Abe T, Kiyonari H, Fujimoto K, Kato Y, Todo T, Matsubara A, Forger D, Takumi T. PLoS Biol. 2014 Apr 15;12(4):e1001839. doi: 10.1371/journal.pbio.1001839. eCollection 2014 Apr. Request this line
  74. Adjuvant-specific regulation of long-term antibody responses by ZBTB20. Wang Y, Bhattacharya D. J Exp Med. 2014 May 5;211(5):841-56. doi: 10.1084/jem.20131821. Epub 2014 Apr 7. Request this line
  75. Impact of genetic background on neonatal lethality of Gga2 gene-trap mice. Doray B, Govero J, Kornfeld S. G3 (Bethesda). 2014 Mar 17;4(5):885-90. doi: 10.1534/g3.114.010355. Request this line
  76. Generation of a cre recombinase-conditional Nos1ap over-expression transgenic mouse. Auer DR, Sysa-Shah P, Bedja D, Simmers JL, Pak E, Dutra A, Cohn R, Gabrielson KL, Chakravarti A, Kapoor A. Biotechnol Lett. 2014 Jun;36(6):1179-85. doi: 10.1007/s10529-014-1473-x. Epub 2014 Feb 22.
  77. Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. Wei Q, Sha Y, Bhattacharya A, Abdel Fattah E, Bonilla D, Jyothula SS, Pandit L, Khurana Hershey GK, Eissa NT.Am J Respir Crit Care Med.. 2014 Jan 1;189(1):16-29. doi: 10.1164/rccm.201305-0874OC.
  78. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Chiang HS, Zhao Y, Song JH, Liu S, Wang N, Terhorst C, Sharpe AH, Basavappa M, Jeffrey KL, Reinecker HC. Nat Immunol. 2014 Jan;15(1):63-71. doi: 10.1038/ni.2766. Epub 2013 Nov 24.
  79. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, Fergusson MM, Rovira II, Allen M, Springer DA, Aponte AM, Gucek M, Balaban RS, Murphy E, Finkel T. Nat Cell Biol. 2013 Dec;15(12):1464-72. doi: 10.1038/ncb2868. Epub 2013 Nov 10. Request this line
  80. Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability. Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA. PLoS One. 2013 Oct 29;8(10):e76973. doi: 10.1371/journal.pone.0076973. eCollection 2013.
  81. Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. Guiraldelli MF, Eyster C, Wilkerson JL, Dresser ME, Pezza RJ. PLoS Genet. 2013 Mar;9(3):e1003383. doi: 10.1371/journal.pgen.1003383. Epub 2013 Mar 21. Request this line
  82. CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Namba T, Tian F, Chu K, Hwang SY, Yoon KW, Byun S, Hiraki M, Mandinova A, Lee SW. Cell Rep. 2013 Oct 31;5(2):331-9. doi: 10.1016/j.celrep.2013.09.020. Epub 2013 Oct 17. Request this line
  83. Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis. Sisay S, Pryce G, Jackson SJ, Tanner C, Ross RA, Michael GJ, Selwood DL, Giovannoni G, Baker D. PLoS One. 2013 Oct 9;8(10):e76907. doi: 10.1371/journal.pone.0076907. eCollection 2013.
  84. Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis. Martínez-Uña M, Varela-Rey M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martínez-Arranz I, García-Rodríguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martínez-Chantar ML, Aspichueta P, Mato JM. Hepatology. 2013 Oct;58(4):1296-305. doi: 10.1002/hep.26399. Epub 2013 Aug 14.
  85. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, Nishitani AM, Yu WM, Goodrich LV. PLoS Genet. 2013;9(9):e1003824. doi: 10.1371/journal.pgen.1003824. Epub 2013 Sep 26. Request this line
  86. Serum TRPM1 autoantibodies from melanoma associated retinopathy patients enter retinal on-bipolar cells and attenuate the electroretinogram in mice. Xiong WH, Duvoisin RM, Adamus G, Jeffrey BG, Gellman C, Morgans CW. PLoS One. 2013 Aug 1;8(8):e69506. doi: 10.1371/journal.pone.0069506. Print 2013.
  87. Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors. Gispert S, Parganlija D, Klinkenberg M, Dröse S, Wittig I, Mittelbronn M, Grzmil P, Koob S, Hamann A, Walter M, Büchel F, Adler T, Hrabé de Angelis M, Busch DH, Zell A, Reichert AS, Brandt U, Osiewacz HD, Jendrach M, Auburger G. Hum Mol Genet. 2013 Dec 15;22(24):4871-87. doi: 10.1093/hmg/ddt338. Epub 2013 Jul 12. Request this line
  88. Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes. López-Garcia C, Ramos-Molina B, Lambertos A, López-Contreras AJ, Cremades A, Peñafiel R. PLoS One. 2013 Jul 12;8(7):e69188. doi: 10.1371/journal.pone.0069188. Print 2013. Request this line
  89. Polymerase delta interacting protein 2 sustains vascular structure and function. Sutliff RL, Hilenski LL, Amanso AM, Parastatidis I, Dikalova AE, Hansen L, Datla SR, Long JS, El-Ali AM, Joseph G, Gleason RL Jr, Taylor WR, Hart CM, Griendling KK, Lassègue B. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2154-61. doi: 10.1161/ATVBAHA.113.301913. Epub 2013 Jul 3. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):e132. Request this line
  90. TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension. Basu R, Lee J, Morton JS, Takawale A, Fan D, Kandalam V, Wang X, Davidge ST, Kassiri Z. Cardiovasc Res. 2013 Jun 1;98(3):360-71. doi: 10.1093/cvr/cvt067. Epub 2013 Mar 21.
  91. Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms. Chang L, Guo R, Huang Q, Yen Y. Cell Rep. 2013 May 30;3(5):1389-97. doi: 10.1016/j.celrep.2013.03.040. Epub 2013 May 2.
  92. Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling. Lin X, Liu B, Yang X, Yue X, Diao L, Wang J, Chang J. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8236-41. doi: 10.1073/pnas.1219995110. Epub 2013 Apr 29. Request this line
  93. A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. Li K, Fichna J, Schicho R, Saur D, Bashashati M, Mackie K, Li Y, Zimmer A, Göke B, Sharkey KA, Storr M. Neuropharmacology. 2013 Aug;71:255-63. doi: 10.1016/j.neuropharm.2013.03.029. Epub 2013 Apr 18.
  94. GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination. Wu CS, Chen H, Sun H, Zhu J, Jew CP, Wager-Miller J, Straiker A, Spencer C, Bradshaw H, Mackie K, Lu HC. PLoS One. 2013;8(4):e60314. doi: 10.1371/journal.pone.0060314. Epub 2013 Apr 2.
  95. A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction. Lee SI, Conrad T, Jones SM, Lagziel A, Starost MF, Belyantseva IA, Friedman TB, Morell RJ. Hear Res. 2013 Jun;300:1-9. doi: 10.1016/j.heares.2013.02.009. Epub 2013 Mar 22. Erratum in: Hear Res. 2013 Aug;302:83.
  96. OLA1 protects cells in heat shock by stabilizing HSP70. Mao RF, Rubio V, Chen H, Bai L, Mansour OC, Shi ZZ. Cell Death Dis. 2013 Feb 14;4:e491. doi: 10.1038/cddis.2013.23.
  97. Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH. PLoS Genet. 2012;8(8):e1002937. doi: 10.1371/journal.pgen.1002937. Epub 2012 Aug 30.
  98. Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. Borkham-Kamphorst E, Zimmermann HW, Gassler N, Bissels U, Bosio A, Tacke F, Weiskirchen R, Kanse SM. J Hepatol. 2013 Jan;58(1):104-11. doi: 10.1016/j.jhep.2012.09.007. Epub 2012 Sep 16. Erratum in: J Hepatol. 2014 Oct;61(4):967.
  99. Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic acidosis: Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct. Bourgeois S, Bounoure L, Christensen EI, Ramakrishnan SK, Houillier P, Devuyst O, Wagner CA. J Biol Chem. 2013 Feb 22;288(8):5518-29. doi: 10.1074/jbc.M112.441782. Epub 2012 Dec 31.
  100. Dact2 represses PITX2 transcriptional activation and cell proliferation through Wnt/beta-catenin signaling during odontogenesis. Li X, Florez S, Wang J, Cao H, Amendt BA. PLoS One. 2013;8(1):e54868. doi: 10.1371/journal.pone.0054868. Epub 2013 Jan 22. Request this line
  101. CLP36 is a negative regulator of glycoprotein VI signaling in platelets. Gupta S, Braun A, Morowski M, Premsler T, Bender M, Nagy Z, Sickmann A, Hermanns HM, Bösl M, Nieswandt B. Circ Res. 2012 Nov 9;111(11):1410-20. doi: 10.1161/CIRCRESAHA.112.264754. Epub 2012 Sep 5. Request this line
  102. The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway. Piatkov KI, Colnaghi L, Békés M, Varshavsky A, Huang TT. Mol Cell. 2012 Dec 28;48(6):926-33. doi: 10.1016/j.molcel.2012.10.012. Epub 2012 Nov 15. Request this line
  103. Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes. Nordstrand LM, Furu K, Paulsen J, Rognes T, Klungland A. Nucleic Acids Res. 2012 Nov;40(21):10950-63. doi: 10.1093/nar/gks839. Epub 2012 Sep 10. Request this line
  104. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ. Circ Res. 2012 Mar 16;110(6):818-30. doi: 10.1161/CIRCRESAHA.111.259663. Epub 2012 Feb 16. Request this line
  105. Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. van Gisbergen KP, Kragten NA, Hertoghs KM, Wensveen FM, Jonjic S, Hamann J, Nolte MA, van Lier RA. Nat Immunol. 2012 Sep;13(9):864-71. doi: 10.1038/ni.2393. Epub 2012 Aug 12. Request this line
  106. G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. Giguère PM, Billard MJ, Laroche G, Buckley BK, Timoshchenko RG, McGinnis MW, Esserman D, Foreman O, Liu P, Siderovski DP, Tarrant TK. Mol Immunol. 2013 Jun;54(2):193-8. doi: 10.1016/j.molimm.2012.12.001. Epub 2012 Dec 29.
  107. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. Ruiz JC, Walker SD, Anderson SA, Eisenstein RS, Bruick RK. J Biol Chem. 2013 Jan 4;288(1):552-60. doi: 10.1074/jbc.M112.426171. Epub 2012 Nov 7.
  108. Age-Dependent MicroRNA Control of Synaptic Plasticity in 22q11 Deletion Syndrome and Schizophrenia. Earls LR, Fricke RG, Yu J, Berry RB, Baldwin LT, Zakharenko SS. J Neurosci.. 2012 Oct 10;32(41):14132-44.
  109. Alanine-Glyoxylate Aminotransferase-2 Metabolizes Endogenous Methylarginines, Regulates NO, and Controls Blood Pressure. Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahey M, Salama A; The International Consortium for Blood Pressure Genome-Wide Association Studies, Wheeler DC, Leiper J. Arterioscler Thromb Vasc Biol. 2012 Sep 27.
  110. The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants. Zelano J, Mikulovic S, Patra K, Kühnemund M, Larhammar M, Emilsson L, Leao R, Kullander K. Exp Neurol. 2012 Sep 26.
  111. Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes. Nordstrand LM, Furu K, Paulsen J, Rognes T, Klungland A. Nucleic Acids Res. 2012 Sep 10.
  112. Protective role of antithrombin in mouse models of liver injury. Guerrero JA, Teruel R, Martínez C, Arcas I, Martínez-Martínez I, de la Morena-Barrio ME, Vicente V, Corral J.J Hepatol. 2012 June 26.
  113. Characterization of an arachidonic acid-deficient (Fads1 knock-out) mouse model. Fan YY, Monk JM, Hou TY, Callaway E, Vincent L, Weeks B, Yang P, Chapkin RS. J Lipid Res. 2012 Apr 25.
  114. Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney. Lier N, Gresko N, Di Chiara M, Loffing-Cueni D, Loffing J. Histochem Cell Biol. 2012 Mar 31.
  115. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD. Science. 2012 Apr 27;336(6080):481-5. doi: 10.1126/science.1217141. Epub 2012 Mar 29.
  116. Phospholipid Scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Talukder AH, Bao M, Kim TW, Facchinetti V, Hanabuchi S, Bover L, Zal T, Liu YJ. Cell Res. 2012 Mar 27.
  117. Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB. Yang C, Jin C, Li X, Wang F, McKeehan WL, Luo Y. PLoS One. 2012 Mar 19.
  118. Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice. Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. J Physiol. 2012 Jan 23.
  119. FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription. De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA, Di Ilio C, Melino G, Sette C, De Laurenzi V. Oncogene. 2012 Feb 2;31(5):573-82.
  120. Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin. Lizak M, Yarovinsky TO. Cell Host Microbe. Cell Host Microbe.2012 Jan 19;11(1):70-80.
  121. Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice. Kempster SL, Belteki G, Licence D, Charnock-Jones DS, Smith GC.Am J Physiol Endocrinol Metab. 2012 Jan;302(1)
  122. Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis. Welsh KJ, Lewis CT, Boyd S, Braun MC, Actor JK. Clin Dev Immunol. 2012;2012:429675
  123. Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants. Villard V, Meunier J, Chevallier N, Maurice T. J Pharmacol Sci. 2011;115(3):279-92.
  124. The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons. Bachy I, Franck MC, Li L, Abdo H, Pattyn A, Ernfors P. Dev Biol. 2011 Dec 1;360(1):77-86.
  125. Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation. Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF. Science. 2011 Nov 11;334(6057):809-13.
  126. Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM Jr. Hypertension. 2011 Oct;58(4):672-8.
  127. Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C. Immunity 2011 Oct 28;35(4):611-21
  128. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC. Nat Immunol. 2011 Aug 28;12(10):1002-9.
  129. Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG. Islets. 2011 May-Jun;3(3):121-8.
  130. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD. Science. 2011 May 6;332(6030):717-21.
  131. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H. Development. 2011 May;138(10):1925-34.
  132. Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B. J. Biol. Chem. 2011 Apr 8;286(14):12271-82.
  133. Traumatic brain injury in mice lacking the K channel, TREK-1. Namiranian K, Brink CD, Goodman JC, Robertson CS, Bryan RM Jr. J Cereb Blood Flow Metab. 2011 Mar;31(3):e1-6.
  134. Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase. Martina Griesberger, Alexander Kollau, Gerald Wölkart, M. Verena Wenzl, Matteo Beretta, Michael Russwurm, Doris Koesling, Kurt Schmidt, Antonius C. F. Gorren, and Bernd Mayer. Mol. Pharmacol. 2011 Mar; 79(3):541-8.
  135. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Liu J, Gao BB, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP. Nat Med. 2011 Feb;17(2):206-10.
  136. RGS6/Gbeta5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Posokhova E, Wydeven N, Allen KL, Wickman K, Martemyanov KA. Circ Res. 2010 Nov 26;107(11):1350-4.
  137. RGS6, a modulator of parasympathetic activation in heart. Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, Li J, Stewart A, Swaminathan PD, Ibeawuchi SR, Shepherd A, Chen CK, Kutschke W, Mohler PJ, Mohapatra DP, Anderson ME, Fisher RA. Circ Res. 2010 Nov 26;107(11):1345-9
  138. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice. Hermanstyne TO, Kihira Y, Misono K, Deitchler A, Yanagawa Y, Misonou H. J Comp Neurol. 2010 Nov 1;518(21):4298-310.
  139. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. Inflamm Bowel Dis. 2011 Aug;17(8):1651-64.
  140. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF. Nat Neurosci. 2010 Sep;13(9):1113-9.
  141. Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Wu CS, Zhu J, Wager-Miller J, Wang S, O’Leary D, Monory K, Lutz B, Mackie K, Lu HC. Eur J Neurosci. 2010 Sep;32(5):693-706
  142. Transient Receptor Potential Melastatin 6 Knockout Mice Are Lethal whereas Heterozygous Deletion Results in Mild Hypomagnesemia. Woudenberg-Vrenken TE, Sukinta A, van der Kemp AW, Bindels RJ, Hoenderop JG. Nephron Physiol. 2010 Sep 1;117(2):p11-p19.
  143. IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50. Conner JR, Smirnova II, Moseman AP, Poltorak A. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11477-82.
  144. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S. Cell Metab. 2010 Apr 7;11(4):311-9.
  145. Characterization of murine SIRT3 transcript variants and corresponding protein products. Yang Y, Hubbard BP, Sinclair DA, Tong Q. J Cell Biochem. 2010 Nov 1;111(4):1051-8.
  146. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ, Bryan RM Jr. Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R461-9.
  147. The SLO3 sperm-specific potassium channel plays a vital role in male fertility. Santi CM, Martínez-López P, de la Vega-Beltrán JL, Butler A, Alisio A, Darszon A, Salkoff L. FEBS Lett. 2010 Mar 5;584(5):1041-6.
  148. Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, Lee E, Gao J, Bredemeyer AL, Helmink BA, Zavadil J, Sleckman BP, Palomero T, Ferrando A, Aifantis I. Nat Immunol. 2010 Mar;11(3):207-15.
  149. RGS7 and -11 Complexes Accelerate the ON-Bipolar Cell Light Response. Jianmei Zhang, Brett G. Jeffrey, Catherine W. Morgans, Neal S. Burke, Tammie L. Haley, Robert M. Duvoisin, and R. Lane Brown. Invest. Ophthalmol. Vis. Sci. 2010 Feb;51(2):1121-9.
  150. DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke W. Tu, X. Xu, L. Peng, X. Zhong, W. Zhang, M. Soundarapandian, C. Balel, M. Wang, N. Jia, W. Zhang, et al. Cell. 2010 Jan 22; 140(2): 222-234.
  151. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Cimen H, Han MJ, Yang Y, Tong Q, Koc H, Koc EC. Biochemistry. 2010 Jan 19;49(2):304-11.
  152. NAD<+>-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. J Biol Chem. 2010 Mar 5;285(10):7417-29.
  153. TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Morgans CW, Zhang J, Jeffrey BG, Nelson SM, Burke NS, Duvoisin RM, Brown RL. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19174-8.
  154. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL 3rd, Goodyear LJ, Tong Q. Aging (Albany NY). 2009 Aug 15;1(9):771-83.
  155. MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN. J Biol Chem. 2009 Feb 27;284(9):5986-93.

TIGM mice cited in patents
  1. USE OF COMPOUNDS ACTIVATING SIRT-3 FOR MIMICKING EXERCISE. David A. Sinclair et al. United States Patent Application Publication. Application number: 12/739,428, Publication number: US 2011/0082189 A1 Filing date: Oct 23, 2008
  2. CLONED TRANSMEMBRANE RECEPTOR FOR 24-HYDROXYLATED VITAMIN D COMPOUNDS AND USES THEREOF. Rene St-Arnaud. US Patent Application 2012/0180142 Filing date: Nov 29, 2011
  3. COMPOSITIONS RELATING TO A PHOSPHOPROTEIN AND METHODS OF USE. US Patent Application 20120204273 Filing date: December 22, 2011. Published on August 9, 2012.
  4. CANCER TREATMENT TARGETING NON-CODING RNA OVEREXPRESSION. Stephen Safe, KyoungHyun Kim. United States Patent Application 20130267575. Filing Date: 03/07/2013; Publication Date: 10/10/2013.
  5. METHODS FOR DIAGNOSING AND TREATING LEARNING OR MENTAL DISORDERS Zakharenko, Stanislav S., Earls, Laurie R. United States Patent Application 20150005365. Filing Date: 02/01/2013, Publication Date: 01/01/2015
  6. METHODS AND COMPOSITIONS FOR INHIBITING GLYOXALASE 1 (GLO1) Palmer, Abraham, Distler, Margaret. United States Patent Application 20160038559 Publication Date: 02/11/2016 Filing Date: 03/12/2014

Publication by TIGM Scientists

 

  1. Sodium-dependent organic anion transporter (Slc10a6-/-) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate. Bakhaus K, Bennien J, Fietz D, Sánchez-Guijo A, Hartmann M, Serafini R, Love CC, Golovko A, Wudy SA, Bergmann M, Geyer J.J Steroid Biochem Mol Biol. 2017 Jul 22. pii: S0960-0760(17)30184-X. doi: 10.1016/j.jsbmb.2017.07.019 [Epub ahead of print]
  2. Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage. Hongmei Cui, Xinsheng Gu, Jingshu Chen, Ying Xie, Sui Ke, Jing Wu, Andrei Golovko, Benjamin Morpurgo, Chunhong Yan, Timothy D. Phillips, Wen Xie, Jianyuan Luo, Zhijun Zhou, Yanan Tian. Toxicology Letters. 18 April 2017. http://doi.org/10.1016/j.toxlet.2017.03.028 [Epub ahead of print]
  3. Absence of Malat1 does not prevent DEN-induced hepatocarcinoma in mice. Miard, S., Girard, M., Joubert, P., Carter, S., Gonzales, A., Guo, H., Morpurgo, B., Boivin, L., Golovko, A., Picard, F. Oncology Reports. 2017 http://dx.doi.org/10.3892/or.2017.5468. [Epub ahead of print] Request this line
  4. The eIF2A knockout mouse.. Golovko A, Kojukhov A, Guan BJ, Morpurgo B, Merrick WC, Mazumder B, Hatzoglou M, Komar AA. Cell Cycle. 2016 Sep 29:0. [Epub ahead of print] Request this line
  5. Nuclear receptor 4A (NR4A) family – orphans no more.. Safe S, Jin UH, Morpurgo B, Abudayyeh A, Singh M, Tjalkens RB. J Steroid Biochem Mol Biol. 2015 Apr 23. pii: S0960-0760(15)00113-2.
  6. Propitious Modulation Fibroblast Quiescence Mediated by Cytokine Expression Mediated from Embryonic Stem Cells.. Shane R, Golovko A, Morpurgo B, Dillberger A, Bonn T, Buz-Zard A. E-Journal of Age Management Medicine. October 2012,.Vol. 7, No 10.
  7. The mammalian gene function resource: the international knockout mouse consortium. . Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Kent Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Francis Stewart A, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. Mamm Genome.2012 Oct;23(9-10):580-6.
  8. Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction. Wallis D, Hill DS, Mendez IA, Abbott LC, Finnell RH, Wellman PJ, Setlow B. Brain Research. 2012 May 7.
  9. Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway.. Boyles AL, Ballard JL, Gorman EB, McConnaughey DR, Cabrera RM, Wilcox AJ, Lie RT, Finnell RH. Hum Reprod.2011 Aug;26(8):2232-8.
  10. A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Salojin KV, Cabrera RM, Sun W, Chang WC, Lin C, Duncan L, Platt KA, Read R, Vogel P, Liu Q, Finnell RH, Oravecz T. Blood. 2011 May 5;117(18):4895-904.
  11. Fuz Controls the Morphogenesis and Differentiation of Hair Follicles through the Formation of Primary Cilia. Daisy Dai, Huiping Zhu, Bogdan Wlodarczyk, Lei Zhang, Li Li, Allen G. Li4, Richard H. Finnell, Dennis R. Roop and Jiang Chen. Journal of Investigative Dermatology 2011 Feb;131(2):302-10.
  12. Fuz regulates craniofacial development through tissue specific responses to signaling factors. Zhang Z, Wlodarczyk BJ, Niederreither K, Venugopalan S, Florez S, Finnell RH, Amendt BA. PLoS One. 2011;6(9)
  13. Teratogenic effects of antiepileptic drugs. Hill DS, Wlodarczyk BJ, Palacios AM, Finnell RH. Expert Rev Neurother. 2010 Jun;10(6):943-59.
  14. Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. Iskandar BJ, Rizk E, Meier B, Hariharan N, Bottiglieri T, Finnell RH, Jarrard DF, Banerjee RV, Skene JH, Nelson A, Patel N, Gherasim C, Simon K, Cook TD, Hogan KJ. J Clin Invest. 2010 May 3;120(5):1603-16.

    Also see commentary:
    Neuronal injury: folate to the rescue? Kronenberg G, Endres M.I. J Clin Invest. 2010 May 3;120(5):1383-6.

  15. High-affinity folate receptor in cardiac neural crest migration: a gene knockdown model using siRNA. Rosenquist TH, Chaudoin T, Finnell RH, Bennett GD. Dev Dyn. 2010 Apr;239(4):1136-44.
  16. Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark. Bille C, Pedersen DA, Andersen AM, Mansilla MA, Murray JC, Christensen K, Ballard JL, Gorman EB, Cabrera RM, Finnell RH. Pediatr Res. 2010 Mar;67(3):274-9.
  17. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Gray RS, Abitua PB, Wlodarczyk BJ, Szabo-Rogers HL, Blanchard O, Lee I, Weiss GS, Liu KJ, Marcotte EM, Wallingford JB, Finnell RH. Nat Cell Biol. 2009 Oct;11(10):1225-32.
  18. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.Jakubowski H, Perla-Kaján J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. FASEB J. 2009 Jun;23(6):1721-7.
  19. Polymorphisms in the neural nicotinic acetylcholine receptor α4 subunit (CHRNA4) are associated with ADHD in a genetic isolate. Wallis D, Arcos-Burgos M, Jain M, Castellanos FX, Palacio JD, Pineda D, Lopera F, Stanescu H, Pineda D, Berg K, Palacio LG, Bailey-Wilson JE, Muenke M. Atten Defic Hyperact Disord. 2009 May;1(1):19-24
  20. Folate Transport and Folate Responsive Developmental Disorders. Gorman EB, Wallis D, Ballard JL, Goin-Kochel RP, Finnell RH. Pteridines. 2009, Vol. 20, Special issue, pp. 156-162.
  21. Review: Genetics of attention deficit/hyperactivity disorder. Wallis D, Russell HF, Muenke M. J Pediatr Psychol. 2008 Nov-Dec;33(10):1085-99
  22. Autoantibodies to folate receptor during pregnancy and neural tube defect risk. Cabrera RM, Shaw GM, Ballard JL, Carmichael SL, Yang W, Lammer EJ, Finnell RH. J Reprod Immunol. 2008 Oct;79(1):85-92.
  23. Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Wong RL, Wlodarczyk BJ, Min KS., Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP and Finnell RH. Hum. Mol. Genet. 2008 Feb 15; 17(4):587-601.

Publication describing our library and technology
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A. Genome Res. 2008 Oct;18(10):1670-9.

Comments are closed.